Cytotoxic secondary metabolites from two strains of endophytic fungi from anthurium loefgrenii

• Grant number: 16/11949-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): September 01, 2016
• Effective date (End): August 31, 2017
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Roberto Gomes de Souza Berlinck
• Grantee: Victor Alves Venâncio
• Host Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil

Abstract

The investigation of unusual microbial sources for the production of bioactive natural products (secondary metabolites ) is of much interest , due to the possibility of obtaining novel compounds with potent biological activities. This project aims at the isolation of unprecedented substances with cytotoxic activity produced by two endophytes P2MF1F1 and isolated from Anthurium P2MSF1F2 loefgrenii collected in Alcatrazes Island ( coast of São Paulo). Fungal strains to be studied were selected because they produced extracts with cytotoxic activity against tumor cells. The objective is to cultivate these strains in larger volumes in order to isolate and completely identify bioactive substances produced in culture media.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BERLINCK, ROBERTO G. S.; MONTEIRO, AFIF F.; BERTONHA, ARIANE F.; BERNARDI, DARLON I.; GUBIANI, JULIANA R.; SLIVINSKI, JULIANO; MICHALISKI, LAMONIELLI F.; TONON, LUCIANE A. C.; VENANCIO, VICTOR A.; FREIRE, VITOR F.. Approaches for the isolation and identification of hydrophilic, light-sensitive, volatile and minor natural products. NATURAL PRODUCT REPORTS, v. 36, n. 7, p. 981-1004, JUL 1 2019. (16/21341-9, 17/06014-4, 16/14375-4, 16/11949-0, 13/50228-8, 17/25100-9)