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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Approaches for the isolation and identification of hydrophilic, light-sensitive, volatile and minor natural products

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Berlinck, Roberto G. S. [1] ; Monteiro, Afif F. [1] ; Bertonha, Ariane F. [1] ; Bernardi, Darlon I. [1] ; Gubiani, Juliana R. [1] ; Slivinski, Juliano [1] ; Michaliski, Lamonielli F. [1] ; Tonon, Luciane A. C. [1] ; Venancio, Victor A. [1] ; Freire, Vitor F. [1]
Total Authors: 10
[1] Univ Sao Paulo, Inst Quim Sao Carlos, CP 780, BR-13560970 Sao Carlos, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: NATURAL PRODUCT REPORTS; v. 36, n. 7, p. 981-1004, JUL 1 2019.
Web of Science Citations: 2

Covering: up to 2019 The discovery of new bioactive natural products gained momentum during the last few decades, resulting from instrumentation advances, from the expansion of genome mining and regulation, as well as by exploration of untapped biological sources. However, water-soluble, volatile, minor and photosensitive natural products are yet poorly known. This review discusses the literature reporting the isolation strategies for some of these metabolites. Analysis of minor metabolites at sub-milligram level are also presented, since analytical instrumentation enabling structure assignment in minute quantities is now routine. Major trends related to natural products discovery are discussed, under the light of further developments in biodiscovery. (AU)

FAPESP's process: 16/21341-9 - Hydrophilic and bioactive secondary metabolites produced by filamentous fungi
Grantee:Darlon Irineu Bernardi
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 17/06014-4 - New secondary metabolites of endophytic and marine organisms as proteasome inhibitors: a validated target against cancer
Grantee:Juliana Regina Gubiani
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 16/14375-4 - Omics tools applied to the discovery of tetrodotoxin producing organisms and biosynthetic genes
Grantee:Luciane Alessandra Chimetto Tonon
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 16/11949-0 - Cytotoxic secondary metabolites from two strains of endophytic fungi from anthurium loefgrenii
Grantee:Victor Alves Venâncio
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 13/50228-8 - Biodiversity components, and their metabolic characters, of Brazilian Islands: an integrated approach
Grantee:Roberto Gomes de Souza Berlinck
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 17/25100-9 - Discovery of bioactive secondary metabolites produced by microbial strains from isolated environments
Grantee:Lamonielli Fagá Michaliski
Support Opportunities: Scholarships in Brazil - Master