Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Oxidative stress and fatty acid profile in Wistar rats subjected to acute food restriction and refeeding with high-fat diets

Full text
Author(s):
da Silva Nassar, Ana Ligia [1] ; Marot, Luisa Pereira [1] ; Ovidio, Paula Payao [2] ; Ferreira de Castro, Gabriela Salim [3] ; Jordao Junior, Alceu Afonso [4]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Internal Med, BR-14049 Ribeirao Preto, SP - Brazil
[2] FMRP USP, Dept Internal Med, Lab Nutr & Metab, Ribeirao Preto, SP - Brazil
[3] FMRP USP, Dept Internal Med, Postgrad Program Internal Med, Ribeirao Preto, SP - Brazil
[4] FMRP USP, Dept Internal Med, Ribeirao Preto, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Acta Cirurgica Brasileira; v. 29, n. 3, p. 178-185, MAR 2014.
Web of Science Citations: 3
Abstract

PURPOSE: To assess oxidative stress and the profile of fatty acids incorporated into the hepatic tissue of animals refed with high-fat (HF) diets after acute food restriction. METHODS: Fifty male Wistar rats were divided into five groups and fasting for 48 hours. One group was sacrificed without refeeding (NR), a control group (C) was refed with the standard AIN-93 diet and the remaining groups with HF diets respectively consisting of hydrogenated vegetable oil (PHVO), trans-free (TF) margarine and trans-free margarine enriched with omega-3 and omega-6 (O). After this period the animals were sacrificed for malondialdehyde (MDA), catalase and hepatic fatty acid determination. RESULTS: The groups refed with HF diets showed elevation of MDA levels compared to the C group (p<0.001 for GVH and p<0.01 for TF and O). Hepatic catalase activity was higher in the TF and O groups compared to group C (p<0.05 for both). The amount of saturated fatty acids was lower in the PHVO and O groups compared to the remaining ones (p<0.001). CONCLUSION: The consumption of high-fat diets after prolonged fasting favors oxidative imbalance in hepatic tissue. (AU)

FAPESP's process: 10/00408-1 - Effects of Fish Oil N-3 Fatty Acids on Lipid Metabolism and Gene Expression in Rats Fed a High-Fructose Diet
Grantee:Gabriela Salim Ferreira de Castro
Support Opportunities: Scholarships in Brazil - Doctorate