High level of resistance to Aztreonam and Ticarcillin in Pseudomonas aeruginosa isolated from soil of different crops in Brazil

Author(s)

Pitondo-Silva, Andre ^[1] ; Martins, Vinicius Vicente ^[1] ; Tonelli Fernandes, Ana Flavia ^[1] ; Stehling, Eliana Guedes ^[1]

Affiliation

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, Ribeirao Preto - Brazil

• Document type: Journal article
• Source: Science of The Total Environment; v. 473, p. 155-158, MAR 1 2014.
• Web of Science Citations: 12

Abstract

Pseudomonas aeruginosa can be found in water, soil, plants and, human and animal fecal samples. It is an important nosocomial pathogenic agent characterized by an intrinsic resistance to multiple antimicrobial agents and the ability to develop high-level (acquired) multidrug resistance through some mechanisms, among them, by the acquisition of plasmids and integrons, which are mobile genetic elements. In this study, 40 isolates from Brazilian soil were analyzed for antibiotic resistance, presence of integrons and plasmidial profile. The results demonstrated that the vast majority of the isolates have shown resistance for aztreonam (92.5%, n = 37) and ticarcillin (85%, n = 34), four isolates presented plasmids and eight isolates possess the class 1 integron. These results demonstrated that environmental isolates of P. aeruginosa possess surprising antibiotic resistance profile to aztreonam and ticarcillin, two antimicrobial agents for clinical treatment of cystic fibrosis patients and other infections occurred by P. aeruginosa. (C) 2014 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 09/16657-3 - Comparative study of Pseudomonas aeruginosa strains isolated from several sources and investigation of antagonism with coliforms group bacteria.
• Grantee: Eliana Guedes Stehling
• Support Opportunities: Regular Research Grants