Cardiovascular effects of a continuous rate infusion of lidocaine in calves anesthetized with xylazine, midazolam, ketamine and isoflurane

Author(s)

Araujo, Marcelo A. ^[1] ; Dias, Bianca P. ^[2] ; Bovino, Fernanda ^[2] ; Deschk, Mauricio ^[2] ; Abimussi, Caio J. X. ^[2] ; Oliva, Valeria N. L. S. ^[2] ; Rodrigues, Celso A. ^[3] ; Santos, Paulo S. P. ^[2]

Affiliation

^[1] Fac Integrated, Dept Vet Med, Campo Mourao, PR - Brazil

^[2] UNESP Sao Paulo State Univ, Dept Clin Surg & Anim Reprod, Fac Vet Med, BR-16050680 Aracatuba, SP - Brazil

^[3] UNESP Sao Paulo State Univ, Fac Vet Med & Zootecnia, Dept Surg & Anesthesiol, Botucatu, SP - Brazil

• Document type: Journal article
• Source: VETERINARY ANAESTHESIA AND ANALGESIA; v. 41, n. 2, p. 145-152, MAR 2014.
• Web of Science Citations: 5

Abstract

Objective To assess the cardiovascular changes of a continuous rate infusion of lidocaine in calves anesthetized with xylazine, midazolam, ketamine and isoflurane during mechanical ventilation. Study design Prospective, randomized, cross-over, experimental trial. Animals A total of eight, healthy, male Holstein calves, aged 10 +/- 1months and weighing 114 +/- 11kg were included in the study. Methods Calves were administered xylazine followed by ketamine and midazolam, orotracheal intubation and maintenance on isoflurane (1.3%) using mechanical ventilation. Forty minutes after induction, lidocaine (2mgkg(-1) bolus) or an equivalent volume of saline (0.9%) was administered IV followed by a continuous rate infusion (100 mu gkg(-1)minute(-1)) of lidocaine (treatment L) or saline (treatment C). Heart rate (HR), systolic, diastolic and mean arterial pressures (SAP, DAP and MAP), central venous pressure (CVP), mean pulmonary arterial pressure (mPAP), pulmonary arterial occlusion pressure (PAOP), cardiac output, end-tidal carbon dioxide (Pe ` CO2) and core temperature (CT) were recorded before lidocaine or saline administration (Baseline) and at 20-minute intervals (T20-T80). Plasma concentrations of lidocaine were measured in treatment L. Results The HR was significantly lower in treatment L compared with treatment C. There was no difference between the treatments with regards to SAP, DAP, MAP and SVRI. CI was significantly lower at T60 in treatment L when compared with treatment C. PAOP and CVP increased significantly at all times compared with Baseline in treatment L. There was no significant difference between times within each treatment and between treatments with regards to other measured variables. Plasma concentrations of lidocaine ranged from 1.85 to 2.06 mu gmL(-1) during the CRI. Conclusion and clinical relevance At the studied rate, lidocaine causes a decrease in heart rate which is unlikely to be of clinical significance in healthy animals, but could be a concern in compromised animals. (AU)

• FAPESP's process: 09/08879-6 - Bispectral index, blood gas analysis and cardiopulmonary parameters of continuous rate infusion of lidocaine in isoflurane anesthetized calves undergoing mechanically ventilation
• Grantee: Paulo Sergio Patto dos Santos
• Support Opportunities: Regular Research Grants
• FAPESP's process: 08/07555-0 - BLOOD GAS ANALYSIS AND CARDIOPULMONARY PARAMETERS OF CONTINUOUS RATE INTRAVENOUS INFUSION OF LIDOCAINE IN ISOFLURANE ANESTHETIZED CALVES UNDERGOING MECHANICALLY VENTILATION
• Grantee: Marcelo Augusto de Araújo
• Support Opportunities: Scholarships in Brazil - Master