Bispectral index, blood gas analysis and cardiopulmonary parameters of continuous rate infusion of lidocaine in isoflurane anesthetized calves undergoing mechanically ventilation

• Grant number: 09/08879-6
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2009
• End date: August 31, 2011
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Paulo Sergio Patto dos Santos
• Grantee: Paulo Sergio Patto dos Santos
• Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil
• City of the host institution: Araçatuba

Abstract

The aim of this study is to evaluate the bispectral index (BIS), cardiorespiratory and acid-base effects in mechanically breathing calves anesthetized by isoflurane and followed by continuous rate infusion of lidocaine. For such, eight male animals with six and eight months old, distributed in two experimental groups lidocaine group (LG) and the control group (CG) will be used. The animals will receive xylazine (0.07 mg/kg;IM) and 15 minutes later, ketamine (1.5 mg/kg; IV) associated with midazolam (0.05 mg/kg; IV). Immediately after the animals will be intubated and submitted to the isoflurane anesthesia (1.3 MAC) and mechanically ventilated. After 20 minutes, the animals of the LG will receive a bolus of 2.0 mg/kg of lidocaine followed by continuous rate infusion of 100 ¼g/kg/min. At the animals of the CG the same amount of sodium chloride 0.9% will be carried out. The observations of the variables HR, SAP, DAP, MAP, RR, ETCO2, SpO2, PaO2, PAO2, PaCO2, SaO2, HCO3, BE, pHa, T0C and BIS in both groups and lidocaíne plasma concentrations at lidocaine group, will begin before (MB) and 15 minutos after (MX) xilazine administration and immediately before (M20) and 20 minutes after (M40) lidocaine or sodium chloride 0.9% continuous rate infusion. New mensurations will be carried out during 60 minutes (in intervals of 20 minutes) M60, M80 e M100, respectively. The lidocaine plasma concentration will be carried out after M40. The recovery time will be evaluated and recorded until de animals have adopted sternal and quadrupedal position. The statistical analysis will be carried out through ANOVA following Bonferroni or t de Student test, considering the level of significance of 5% (p<0.05). (AU)

Scientific publications

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

ARAUJO, MARCELO A.; DIAS, BIANCA P.; BOVINO, FERNANDA; DESCHK, MAURICIO; ABIMUSSI, CAIO J. X.; OLIVA, VALERIA N. L. S.; RODRIGUES, CELSO A.; SANTOS, PAULO S. P.. Cardiovascular effects of a continuous rate infusion of lidocaine in calves anesthetized with xylazine, midazolam, ketamine and isoflurane. VETERINARY ANAESTHESIA AND ANALGESIA, v. 41, n. 2, p. 145-152, MAR 2014. (09/08879-6, 08/07555-0)