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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Tendon structural adaptations to load exercise are inhibited by anabolic androgenic steroids

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Author(s):
Marqueti, R. C. [1] ; Paulino, M. G. [2] ; Fernandes, M. N. [2] ; de Oliveira, E. M. [3] ; Selistre-de-Araujo, H. S. [2]
Total Authors: 5
Affiliation:
[1] Univ Brasilia, Fac Ceilandia, BR-72220900 Brasilia, DF - Brazil
[2] Univ Fed Sao Carlos, Dept Physiol Sci, BR-13560 Sao Carlos, SP - Brazil
[3] Univ Sao Paulo, Sch Phys Educ & Sports, Lab Biochem, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS; v. 24, n. 1, p. e39-e51, FEB 2014.
Web of Science Citations: 5
Abstract

The present study investigated the structural changes in the rat calcaneal tendon (CT), superficial flexor tendon (SFT), and deep flexor tendon (DFT) in response to jump exercises and anabolic androgenic steroids (AAS). Animals were divided into four groups: sedentary, trained, AAS-treated sedentary rats, and AAS-treated trained animals. Training increased the volume density (Vv%) of blood vessels in all regions of the CT and DFT, cell Vv% in the peritendinous sheath of the proximal and distal regions of the SFT and proximal region of DFT, and cell Vv% in the tendon proper of the proximal and distal regions of the SFT and DFT. The combination of AAS and load exercises showed little increased blood vessel Vv% at the proximal region of the CT, intermediate region of the SFT, and all regions of the DFT as opposed to an increase in adipose cell Vv% in the CT proximal region. The AAS reduced the levels of hydroxyproline in the proximal region of the DFT and in the distal region of the STF. In conclusion, exercise promoted benefits to the adaptation of the tendons to overload. These effects were absent when load exercise was combined with AAS. The abusive consumption of AAS contributes to tendon inertness and rigidity, and increases the potential risk of injury. (AU)

FAPESP's process: 10/19390-5 - Aging-related alterations in extracellular matrix and its adaptations to strength training in Calcaneal tendon of rats: molecular, cellular, and biomechanical approach.
Grantee:Rita de Cássia Marqueti Durigan
Support Opportunities: Scholarships in Brazil - Post-Doctoral