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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

ACUTE EXERCISE-INDUCED ACTIVATION OF PHOX2B-EXPRESSING NEURONS OF THE RETROTRAPEZOID NUCLEUS IN RATS MAY INVOLVE THE HYPOTHALAMUS

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Author(s):
Barna, B. F. [1] ; Takakura, A. C. [2] ; Moreira, T. S. [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Pharmacol, Inst Biomed Sci, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Neuroscience; v. 258, p. 355-363, JAN 31 2014.
Web of Science Citations: 25
Abstract

The rat retrotrapezoid nucleus (RTN) contains neurons that have a well-defined phenotype characterized by the presence of vesicular glutamate transporter 2 (VGLUT2) mRNA and a paired-like homeobox 2b (Phox2b)-immunoreactive (ir) nucleus and the absence of tyrosine hydroxylase (TH). These neurons are important to chemoreception. In the present study, we tested the hypothesis that the chemically-coded RTN neurons (ccRTN) (Phox2b(+)/TH-) are activated during an acute episode of running exercise. Since most RTN neurons are excited by the activation of perifornical and lateral hypothalamus (PeF/LH), a region that regulates breathing during exercise, we also tested the hypothesis that PeF/LH projections to RTN neurons contribute to their activation during acute exercise. In adult male Wistar rats that underwent an acute episode of treadmill exercise, there was a significant increase in c-Fos immunoreactive (c-Fos-ir) in PeF/LH neurons and RTN neurons that were Phox2b(+)/TH- (p< 0.05) compared to rats that did not exercise. Also the retrograde tracer Fluoro-Gold that was injected into RTN was detected in c-Fos-ir PeF/LH (p < 0.05). In summary, the ccRTN neurons (Phox2b(+)/TH-) are excited by running exercise. Thus, ccRTN neurons may contribute to both the chemical drive to breath and the feed-forward control of breathing associated with exercise. (C) 2013 IBRO. Published by Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 10/12590-9 - Interaction between hipothalamic areas and the retroprapezoid nucleus in control of central chemosensitivity
Grantee:Bárbara Falquetto
Support type: Scholarships in Brazil - Master
FAPESP's process: 10/09776-3 - Neural mechanisms involved in expiratory rhythm generator: possible involvement of the retrotrapezoid nucleus and the parafacial region
Grantee:Ana Carolina Thomaz Takakura
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 10/19336-0 - Pontine mechanisms involved in cardiorespiratory control during central or peripheral chemoreceptors activation
Grantee:Thiago dos Santos Moreira
Support type: Regular Research Grants