Neurotransmitter receptor and regulatory gene expression in peripheral blood of Brazilian drug-naive first-episode psychosis patients before and after antipsychotic treatment

Author(s)

Ota, Vanessa Kiyomi ^{[1, 2]} ; Noto, Cristiano ^[2] ; Gadelha, Ary ^[2] ; Santoro, Marcos Leite ^{[1, 2]} ; Silva, Patricia Natalia ^{[1, 2]} ; Melaragno, Maria Isabel ^[1] ; Cardoso Smith, Marilia de Arruda ^[1] ; Cordeiro, Quirino ^[3] ; Bressan, Rodrigo Affonseca ^[2] ; Belangero, Sintia Iole ^{[1, 2]}

Affiliation

^[1] Univ Fed Sao Paulo, Disciplina Genet, Dept Morfol & Genet, BR-04023900 Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Dept Psiquiatria, LiNC, BR-05039032 Sao Paulo - Brazil

^[3] ISCMSP, Dept Psiquiatria, Sao Paulo - Brazil

• Document type: Journal article
• Source: PSYCHIATRY RESEARCH; v. 210, n. 3, p. 1290-1292, DEC 30 2013.
• Web of Science Citations: 8

Abstract

Little is known about how genes expressed in blood relate to schizophrenia or antipsychotic use. We analyzed gene expression in 10 first-episode psychosis patients and nine controls using PCR Arrays. GABRR2 and CHRNA3 were found to be differentially expressed after risperidone treatment. These genes may be regulated by antipsychotic use. (C) 2013 Elsevier Ireland Ltd. All rights reserved. (AU)

• FAPESP's process: 10/08968-6 - Investigation of genetic and epigenetic markers: a translational approach for schizophrenia treatment
• Grantee: Síntia Iole Nogueira Belangero
• Support Opportunities: Regular Research Grants
• FAPESP's process: 11/50740-5 - Prevention in schizophrenia and bipolar disorder from neuroscience to the community: a multiphase, multimodal and translational platform for research and intervention
• Grantee: Rodrigo Affonseca Bressan
• Support Opportunities: Research Projects - Thematic Grants