MODULATION OF HALOPERIDOL-INDUCED CATALEPSY IN RATS BY GABAERGIC NEURAL SUBSTRATE IN THE INFERIOR COLLICULUS

Author(s)

Tostes, J. G. ^{[1, 2]} ; Medeiros, P. ^[3] ; Melo-Thomas, L. ^{[3, 4]}

Affiliation

^[1] Univ Sao Francisco, Lab Neuropsicofarmacol, BR-12916900 Braganca Paulista, SP - Brazil

^[2] Fac Med Itajuba, BR-37502138 Itajuba, MG - Brazil

^[3] Univ Fed Sao Paulo, Dept Biociencias, BR-11060001 Santos, SP - Brazil

^[4] Inst Neurociencias & Comportamento INeC, BR-14040901 Ribeirao Preto, SP - Brazil

• Document type: Journal article
• Source: Neuroscience; v. 255, p. 212-218, DEC 26 2013.
• Web of Science Citations: 10

Abstract

Not only is the inferior colliculus (IC) a highly important center of integration within the central auditory pathway, but it may also play a modulatory role in sensorymotor circuitry. Previous evidence from our laboratory relating the IC to motor behavior shows that glutamate-mediated mechanisms within the IC modulate haloperidol-induced catalepsy. The high density of GABAergic receptors in the IC led to this study of a possible link between these receptors, haloperidol-induced catalepsy, and a possible involvement of the blockade of dopaminergic receptors. Catalepsy was evaluated by positioning both forepaws of rats on an elevated horizontal wooden bar and recording the time that the animal maintained this position. The present study shows that haloperidol-induced catalepsy was enhanced by local microinjection into the IC of midazolam (20 nmol/0.5 mu l), a benzodiazepine receptor agonist, whereas animals receiving a microinjection of bicuculline (40 or 80 ng/0.5 mu l), a GABAergic antagonist, showed a reduction in the time of catalepsy. However, the microinjection of haloperidol (2.5 or 5.0 mu g/0.5 mu l) bilaterally into the IC did not induce catalepsy. Therefore, our results suggest the involvement of the IC in the modulation of catalepsy induced by haloperidol, even though the dopaminergic mechanisms of the IC are unable to induce catalepsy when blocked by the direct microinjection of haloperidol. It is thus possible that the IC plays a role in sensorimotor gating and that GABA-mediated mechanisms are involved. (C) 2013 IBRO. Published by Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 09/01437-8 - Investigation of glutamatergic neurotransmission mediated by NMDA receptors in the inferior colliculus in catalepsy induced by haloperidol
• Grantee: Liana Melo-Thomas
• Support Opportunities: Regular Research Grants
• FAPESP's process: 11/01409-4 - Electrical stimulation and recording of the neural activity into the inferior colliculus during the haloperidol-induced catalepsy: a behavioral and electrophysiologic study
• Grantee: Liana Melo-Thomas
• Support Opportunities: Regular Research Grants