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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Pathogen levels and clinical response to periodontal treatment in patients with Interleukin 8 haplotypes

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Author(s):
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Finoti, Livia S. [1] ; Corbi, Samia C. T. [1] ; Anovazzi, Giovana [1] ; Teixeira, Silvia R. L. [2] ; Capela, Marisa V. [3] ; Tanaka, Marcia H. [4] ; Kim, Yeon J. [1] ; Orrico, Silvana R. P. [1] ; Cirelli, Joni A. [1] ; Mayer, Marcia P. A. [2] ; Scarel-Caminaga, Raquel M. [4]
Total Authors: 11
Affiliation:
[1] UNESP Univ Estadual Paulista, Sch Dent Araraquara, Dept Oral Diag & Surg, BR-14801903 Araraquara, SP - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo - Brazil
[3] UNESP Univ Estadual Paulista, Inst Chem Araraquara, Dept Phys Chem, BR-14801903 Araraquara, SP - Brazil
[4] UNESP Univ Estadual Paulista, Sch Dent Araraquara, Dept Morphol, BR-14801903 Araraquara, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: PATHOGENS AND DISEASE; v. 69, n. 1, p. 21-28, OCT 2013.
Web of Science Citations: 3
Abstract

The aim of this study was to investigate the effect of non-surgical treatment of periodontitis on the levels of periodontopathogens and clinical parameters in patients with different genetic backgrounds produced by polymorphisms in the Interleukin (IL8) gene. Thirty patients grouped according to IL8 ATC/TTC or AGT/TTC haplotypes were submitted to non-surgical periodontal treatment. Levels of Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola were determined in 240 subgingival plaque samples by qPCR. The association between IL8 haplotypes and the levels of periodontopathogens and clinical parameters was investigated by multilevel analysis accounting for the clustering of diseased sites analyzed within patients. It was observed that neither levels of periodontopathogens nor non-surgical treatment was associated with the IL8 haplotype. The clinical parameters after periodontal treatment were similar in diseased and healthy sites, independently of the IL8 haplotype. Nonetheless, in the same period, diseased sites of AGT/TTC patients harbored higher levels of P. gingivalis, T. denticola, T. forsythia, and red complex than those of ATC/TTC patients. However, the non-surgical periodontal therapy decreased the levels of these periodontopathogens and of the tested clinical parameters of diseased sites in both groups. Non-surgical therapy is equally effective in improving clinical parameters and decreasing the levels of periodontopathogens, independent of the genotype groups produced by the IL8 haplotype. (AU)

FAPESP's process: 09/11371-4 - COMPARATIVE INVESTIGATION OF CLINICAL AND MICROBIOLOGICAL DATA BETWEEN GENETICALLY SUSCEPTIBLE INDIVIDUALS AND NOT SUSCETIBLE TO PERIODONTITIS
Grantee:Livia Sertori Finoti
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 09/08773-3 - Clinical, microbiological and imunological analyses in individuals with genetic susceptibility to periodontal disease
Grantee:Raquel Mantuaneli Scarel Caminaga
Support Opportunities: Regular Research Grants
FAPESP's process: 03/10424-0 - Investigation of polymorphisms in the promoter region of interleukin 8 in Brazilian individuals with chronic periodontitits
Grantee:Raquel Mantuaneli Scarel Caminaga
Support Opportunities: Regular Research Grants