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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effect of fertilisation and harvest period on polar metabolites of Calendula oficcinalis

Author(s):
Alves Fernandes, Eduardo Felipe [1] ; Meloni, Fernando [2] ; Borella, Julio Cezar [3] ; Lopes, Norberto Peporine [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Quim & Fis, BR-14049 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, BR-14049 Ribeirao Preto, SP - Brazil
[3] Univ Ribeirao Preto UNAERP, Disciplina Farmacognosia, Curso Ciencias Farmaceut, Ribeirao Preto, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 23, n. 5, p. 731-735, SEP-OCT 2013.
Web of Science Citations: 3
Abstract

The present study evaluated the chemical profile of polar extracts of Calendula officinalis L., Asteraceae, that were grown under different cultivation conditions: chemical fertilisation, organic fertilisation and mulching. Furthermore, we investigated metabolite variations during plant development by comparing the metabolites from harvested plants at 60 and 120 days after planting. We used HPLC-DAD-MS/MS to tentatively identify metabolites. In total, we identified seven known compounds: five flavonoid glycosides and two caffeoylquinic acids derivatives. There were no statistically significant differences in the expression of metabolites from plants grown under the examined soil treatments. However, five substances varied according to harvest time, suggesting that the biosynthesis of polar metabolites of Calendula officinalis is not affected by changes in soil composition. Therefore, this plant could represent a source for phytomedicines with a constant content of polar metabolites. (C) 2013 Elsevier Editora Ltda. All rights reserved. (AU)

FAPESP's process: 09/51812-0 - Development of a platform for the study of in vitro and in vivo metabolism of natural products, a need for pre-clinical testing system
Grantee:Norberto Peporine Lopes
Support type: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 13/06196-4 - Study of edaphic and epigeic communities as self-organized complex systems
Grantee:Fernando Meloni
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 09/00940-8 - Qualitative study of polar metabolites from inflorescences of calendula (Calendula officinalis L., Calendulae, Asteraceae): evaluation of different cultivation conditions
Grantee:Eduardo Felipe Alves Fernandes
Support type: Scholarships in Brazil - Scientific Initiation