Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Actions of oestradiol and progesterone on the prostate in female gerbils: reversal of the histological effects of castration

Full text
Author(s):
Zanatelli, Marianna [1] ; Silva, Diego A. L. [1] ; Shinohara, Filipe Z. [1] ; Goes, Rejane M. [2] ; Santos, Fernanda C. A. [3] ; Vilamaior, Patricia S. L. [2] ; Taboga, Sebastiao R. [2]
Total Authors: 7
Affiliation:
[1] Univ Estadual Campinas, Inst Biol, Dept Cell Biol, BR-13083970 Campinas, SP - Brazil
[2] Sao Paulo State Univ, Dept Biol, Lab Microscopy & Microanal, BR-15054000 Sao Paulo - Brazil
[3] Univ Fed Goias, Inst Biol Sci, Dept Morphol, BR-74001970 Goiania, Go - Brazil
Total Affiliations: 3
Document type: Journal article
Source: REPRODUCTION FERTILITY AND DEVELOPMENT; v. 26, n. 4, p. 540-550, 2014.
Web of Science Citations: 4
Abstract

The female prostate is a functionally active gland in several mammalian species, including humans and rodents. Investigations of prostate morphophysiology during the phases of the oestrous cycle have shown that the female prostate is influenced by fluctuations in serum concentrations of oestradiol (E2) and progesterone (P4). The aim of the present study was to evaluate the effect of combined prolonged administration of E2 and P4 on the prostate in ovariectomised female gerbils. Ovariectomy caused atrophy and decreased glandular secretory activity. Administration of E2 and P4 (0.1 mg kg(-1) diluted in 0.1 mL of mineral oil, every 48 h over 30 days) resulted in a recovery of overall prostate structure, as evidenced by increased epithelial height, mass and prostatic secretory activity, without leading the appearance of significant lesions. Evaluation of androgen receptor (AR) expression revealed increased immunoreactivity in the E2+P4-treated group. Immunostaining for oestrogen receptor (ER) alpha was decreased in the castrated groups, but increased in the group subjected to hormone treatment. There were no significant differences in ER beta immunoreactivity among the groups. Assessment of cell proliferation revealed greater immunoreactivity in the treated group. Together, the results indicate that the interaction between E2 and P4 may be responsible for maintaining female prostate gland histophysiology. (AU)

FAPESP's process: 09/12688-1 - Morphofunctional aspects of the gerbil female prostate during the estrus cycle: Effects of ovariectomy followed by prolongated oestradiol and progesterone hormonal reposition
Grantee:Marianna Zanatelli
Support Opportunities: Scholarships in Brazil - Master