Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Influence of TLR-2 in the immune response in the infection induced by fungus Sporothrix schenckii

Full text
Author(s):
Negrini, Thais de C. [1] ; Ferreira, Lucas S. [1] ; Arthur, Rodrigo A. [2] ; Alegranci, Pamela [1] ; Placeres, Marisa C. P. [1] ; Spolidorio, Luis C. [3] ; Carlos, Iracilda Z. [1]
Total Authors: 7
Affiliation:
[1] Sao Paulo State Univ, Araraquara Sch Pharmaceut Sci, Dept Clin Anal, BR-14801902 Araraquara, SP - Brazil
[2] Univ Fed Rio Grande do Sul, Sch Dent, Dept Prevent & Community Dent, BR-90046900 Porto Alegre, RS - Brazil
[3] Sao Paulo State Univ, Araraquara Sch Dent, Dept Physiol & Pathol, BR-14801902 Araraquara, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: IMMUNOLOGICAL INVESTIGATIONS; v. 43, n. 4, p. 370-390, 2014.
Web of Science Citations: 12
Abstract

Toll-like receptors (TLRs) play an important role in immunity, since they bind to pathogen surface antigens and initiate the immune response. However, little is known about the role of TLR-2 in the recognition of S. schenckii and in the subsequent immune response. Therefore, the aim of this study was to evaluate the involvement of TLR-2 in the immune response induced by S. schenckii. C57BL/6 mice (WT) and C57BL/6 TLR-2 knockout (TLR-2(-/-)) were used to evaluate, over a period of 10 weeks of sporotrichotic infection, the influence of TLR-2 over macrophages production of IL-1 beta, IL-12 and TNF-alpha, their stimulation level by NO release and the production of IFN-gamma, IL-6, IL-17 and TGF-beta by spleen cells. The results showed that the production of pro-inflammatory mediators and NO, TLR-2 interference is striking, since its absence completely inhibited it. IL-17 production was independent of TLR-2. The absence of Th1 response in TLR2(-/-) animals was concomitant with IL-17 production. Therefore, it can be suggested that TLR-2 absence interferes with the course of the infection induced by the fungus S. schenckii. (AU)

FAPESP's process: 09/11999-3 - Influence of TLR-2 and TLR-4 receptors in host defense against the fungus Sporothrix schenckii
Grantee:Iracilda Zeppone Carlos
Support Opportunities: Regular Research Grants
FAPESP's process: 09/07529-1 - Influence of TLR-2 receptors in host defense against the fungus Sporothrix schenckii
Grantee:Thais de Cassia Negrini
Support Opportunities: Scholarships in Brazil - Doctorate