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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Leukocyte-mediated Tissue Injury in Ischemic Stroke

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Author(s):
Rodrigues, S. F. [1] ; Granger, D. N. [2]
Total Authors: 2
Affiliation:
[1] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, BR-05508 Sao Paulo - Brazil
[2] Louisiana State Univ, Dept Mol & Cellular Physiol, Shreveport, LA 71130 - USA
Total Affiliations: 2
Document type: Journal article
Source: Current Medicinal Chemistry; v. 21, n. 19, p. 2130-2137, JUN 2014.
Web of Science Citations: 11
Abstract

Ischemic stroke remains a leading cause of death worldwide. While the underlying causes of stroke remain poorly defined, brain inflammation appears to be a characteristic response to the vascular insult and there is growing evidence suggesting a cause-effect relationship between the inflammatory response and stroke-induced brain dysfunction and tissue injury. In this review, we summarize evidence that implicates leukocytes in the pathophysiology of stroke and address some of the mediators that contribute to the recruitment and activation of leukocytes in the post-ischemic brain. The products of leukocyte activation that may account for the deleterious effects of this cell population in stroke is also discussed. Recently tested compounds that afford protection against the neurological deficits and tissue injury induced by stroke are addressed within the context of potential development of novel strategies for stroke treatment. (AU)

FAPESP's process: 11/02438-8 - THERAPEUTIC EFFICACY OF INDOMETHACIN AND INDOMETHACIN ETHYL ESTER NANOCAPSULES IN THE CEREBRAL MICROCIRCULATION OF MICE: IN VIVO AND EX VIVO STUDIES
Grantee:Stephen Fernandes de Paula Rodrigues
Support Opportunities: Scholarships in Brazil - Post-Doctoral