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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Synthesis, antioxidant and photoprotection activities of hybrid derivatives useful to prevent skin cancer

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Author(s):
Reis, Juliana Santana [1] ; Correa, Marcos Antonio [1] ; Chung, Man Chin [1] ; dos Santos, Jean Leandro [1]
Total Authors: 4
Affiliation:
[1] Univ Estadual Paulista UNESP, Fac Ciencias Farmaceut, Dept Farmacos & Medicamentos, Lapdesf Lab Pesquisa & Desenvolvimento Farmacos, BR-14801902 Araraquara, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Bioorganic & Medicinal Chemistry; v. 22, n. 9, p. 2733-2738, MAY 1 2014.
Web of Science Citations: 13
Abstract

Chronic ultraviolet (UV) radiation exposure is a major cause of skin cancer. A novel series of hybrid derivatives (I-VIII) for use in sunscreen formulations were synthesized by molecular hybridization of t-resveratrol, avobenzone, and octyl methoxycinnamate, and were characterized. The antioxidant activity values for VIII were comparable than to those of t-resveratrol. Compounds I-III and VI demonstrated Sun Protector Factor superior to that of t-resveratrol. Compounds I and IV-VIII were identified as new, broad-spectrum UVA filters while II-III were UVB filters. In conclusion, novel hybrid derivatives with antioxidant effects have emerged as novel photoprotective agents for the prevention of skin cancer. (C) 2014 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 12/09237-0 - Design, Synthesis and Evaluation of new photoprotective hybrids compounds derivatives from resveratrol, cinnamates and avobenzone planned as sunscreens
Grantee:Juliana Santana Reis
Support Opportunities: Scholarships in Brazil - Master