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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Sickle cell disease: challenges and advances in drug discovery

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Author(s):
Jean Leandro dos Santos [1] ; Chung Man Chin [2]
Total Authors: 2
Affiliation:
[1] Universidade Estadual Paulista Júlio de Mesquita Filho. Faculdade de Ciências Farmacêuticas - Brasil
[2] Universidade Estadual Paulista Júlio de Mesquita Filho. Faculdade de Ciências Farmacêuticas - Brasil
Total Affiliations: 2
Document type: Journal article
Source: Química Nova; v. 35, n. 4, p. 783-790, 2012-00-00.
Abstract

Sickle Cell Disease (SCD) is a disease characterized by a punctual mutation (GTG - GAG) in the sixth codon of the gamma globin gene leading to a substitution of glutamic acid by a valine in the β chain of hemoglobin. Despite the huge progress on the molecular knowledge of the disease in recent years, few therapeutic resources were developed. Currently, the treatment is mainly done with the anticancer agent hydroxyurea. This review summarizes current knowledge about possible targets and new approaches to the discovery new compounds to treat the symptoms of SCD. (AU)

FAPESP's process: 10/12495-6 - Optimization, synthesis and pharmacological evaluation of new drug candidates to treat the symptoms of sickle cell disease
Grantee:Jean Leandro dos Santos
Support Opportunities: Regular Research Grants