Three-component reaction for the synthesis of diverse beta-unsaturated alpha-amino esters

Stefani, Helio A.; Manarin, Flavia; Sousa, Ariane C. S.; Souza, Frederico B.; Ferraz, Witor Ribeiro

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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Three-component reaction for the synthesis of diverse beta-unsaturated alpha-amino esters

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Author(s):	Stefani, Helio A. ^[1] ; Manarin, Flavia ^[2] ; Sousa, Ariane C. S. ^[1] ; Souza, Frederico B. ^[1] ; Ferraz, Witor Ribeiro ^[1] Total Authors: 5
Affiliation:	^[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farm, BR-05508900 Sao Paulo - Brazil ^[2] Univ Estadual Oeste Parana, Ctr Engn & Ciencias Exacts, Guarapuava, PR - USA Total Affiliations: 2
Document type:	Journal article
Source:	Tetrahedron; v. 70, n. 20, p. 3243-3248, MAY 20 2014.
Web of Science Citations:	5
Abstract
We describe an efficient multicomponent reaction for the preparation of beta-unsaturated alpha-amino esters by ytterbium triflate catalyzed reaction of potassium organotrifluoroborate salts, aniline and ethyl glyoxalate. The synthetic viability of this protocol was demonstrated by moderate to high yields, short reaction time ranging from 0.5 to 12 h, and efficiency with respect to substrate scope. (C) 2013 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process:	12/00424-2 - Synthesis of small libraries using potassium Organotrifluoroborates in Suzuki-Miyaura reactions
Grantee:	Helio Alexandre Stefani
Support Opportunities:	Research Projects - Thematic Grants

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