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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

NMDA and AMPA/Kainate Glutamatergic Receptors in the Prelimbic Medial Prefrontal Cortex Modulate the Elaborated Defensive Behavior and Innate Fear-Induced Antinociception Elicited by GABA(A) Receptor Blockade in the Medial Hypothalamus

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Author(s):
de Freitas, Renato Leonardo [1, 2] ; Salgado-Rohner, Carlos Jose [1] ; Biagioni, Audrey Francisco [1, 2] ; Medeiros, Priscila [1, 3, 2] ; Cecilio Hallak, Jaime Eduardo [4, 5] ; Crippa, Jose Alexandre S. [4, 5] ; Coimbra, Norberto Cysne [1, 2, 6]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Farmacol, Lab Neuroanat & Neuropsicobiol, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Inst Neurociencias & Comportamento INeC, BR-14040901 Ribeirao Preto, SP - Brazil
[3] Univ Fed Sao Paulo UNIFESP, Dept Biociencias, BR-1060001 Santos, SP - Brazil
[4] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Neurociencias & Ciencias Comportament, Setor Psiquiatria, BR-14049900 Ribeirao Preto, SP - Brazil
[5] Univ Fed Rio Grande do Sul, CNPq, Natl Inst Sci & Translat Technol Med INCT TM, Porto Alegre, RS - Brazil
[6] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Farmacol, NAP USP Neurobiol Emocoes NuPNE, BR-14049900 Ribeirao Preto, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: CEREBRAL CORTEX; v. 24, n. 6, p. 1518-1528, JUN 2014.
Web of Science Citations: 15
Abstract

The aim of the present study was to investigate the involvement of N-methyl-d-aspartate (NMDA) and amino-3-hydroxy-5-methyl-isoxazole-4-proprionate (AMPA)/kainate receptors of the prelimbic (PL) division of the medial prefrontal cortex (MPFC) on the panic attack-like reactions evoked by gamma-aminobutyric acid-A receptor blockade in the medial hypothalamus (MH). Rats were pretreated with NaCl 0.9%, LY235959 (NMDA receptor antagonist), and NBQX (AMPA/kainate receptor antagonist) in the PL at 3 different concentrations. Ten minutes later, the MH was treated with bicuculline, and the defensive responses were recorded for 10 min. The antagonism of NMDA receptors in the PL decreased the frequency and duration of all defensive behaviors evoked by the stimulation of the MH and reduced the innate fear-induced antinociception. However, the pretreatment of the PL cortex with NBQX was able to decrease only part of defensive responses and innate fear-induced antinociception. The present findings suggest that the NMDA-glutamatergic system of the PL is critically involved in panic-like responses and innate fear-induced antinociception and those AMPA/kainate receptors are also recruited during the elaboration of fear-induced antinociception and in panic attack-related response. The activation of the glutamatergic neurotransmission of PL division of the MPFC during the elaboration of oriented behavioral reactions elicited by the chemical stimulation of the MH recruits mainly NMDA receptors in comparison with AMPA/kainate receptors. (AU)

FAPESP's process: 08/08955-1 - Involvement of the Dorsal Raphe Nucleus Neural Networks and Serotonergic Neurotransmittion in the Locus Coeruleus in Antinociceptive Processess Induced by Oriented Escape Reaction Evoked by Chemical Stimulation of the Medial Hypothalamus.
Grantee:Audrey Franceschi Biagioni
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 10/15140-4 - Neuropharmacological study of the involvement of dorsal rafe nucleus and serotoninergic systems in the antinociceptive process induced by oriented escape reaction evoked by GABAergic disinhibition of the dorsomedial hypothalamus
Grantee:Audrey Franceschi Biagioni
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 10/14446-2 - Involvement of the glutamatergic neurotransmission in the inferior colliculus on the catalepsy induced by intraestriatal haloperidol microinjection
Grantee:Priscila Medeiros de Freitas
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 09/17258-5 - Study of the involvement of nitrergic system and of glutamatergic and cannabinoid-mediated neurotransmission from the medial prefrontal cortex in the analgesia induced by elaborated escape reactions evoked by GABAergic blockade in the medial hypothalamus
Grantee:Renato Leonardo de Freitas
Support Opportunities: Scholarships in Brazil - Post-Doctoral