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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Post-immobilization eccentric training promotes greater hypertrophic and angiogenic responses than passive stretching in muscles of weanling rats

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Author(s):
Oliveira Benedini-Elias, Priscila Cacao [1] ; Morgan, Mariana Calvente [1] ; Cornachione, Anabelle Silva [1] ; Martinez, Edson Z. [2] ; Mattiello-Sverzut, Ana Claudia [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Biomecan Med & Reabilitacao Aparelho Locomot, Lab Pesquisa Cient, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Social Med, BR-14049900 Ribeirao Preto, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: ACTA HISTOCHEMICA; v. 116, n. 3, p. 503-513, 2014.
Web of Science Citations: 2
Abstract

This study investigated how different types of remobilization after hind limb immobilization, eccentric exercise and passive static stretching, influenced the adaptive responses of muscles with similar function and fascicle size, but differing in their contractile characteristics. Female Wistar weanling rats (21 days old) were divided into 8 groups: immobilized for 10 days, maintaining the ankle in maximum plantar flexion; immobilized and submitted to eccentric training for 10 or 21 days on a declining treadmill for 40 min; immobilized and submitted to passive stretching for 10 or 21 days for 40 min by maintaining the ankle in maximum dorsiflexion; control of immobilized; and control of 10 or 21 days. The soleus and plantaris muscles were analyzed using fiber distribution, lesser diameter, capillary/fiber ratio, and morphology. Results showed that the immobilization reduced the diameter of all fiber types, caused changes in fiber distribution and decreased the number of transverse capillaries in both muscles. The recovery period of the soleus muscle is longer than that of the plantaris after detraining. Moreover, eccentric training induced greater hypertrophic and angiogenic responses than passive stretching, especially after 21 days of rehabilitation. Both techniques demonstrated positive effects for muscle rehabilitation with the eccentric exercise being more effective. (C) 2013 Elsevier GmbH. All rights reserved. (AU)