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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Clinical determinants and prognostic significance of the electrocardiographic strain pattern in chronic kidney disease patients

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Author(s):
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Cordeiro, Antonio C. [1] ; Moraes, Aline A. I. [1] ; Cerutti, Virginia [2] ; Franca, Faustino [2] ; Quiroga, Borja [3] ; Amodeo, Celso [1] ; Picotti, Juliano C. [4] ; Dutra, Lucas V. [4] ; Rodrigues, Gabriel D. [4] ; Amparo, Femanda C. [5] ; Lindholm, Bengt [6, 1, 7] ; Carrero, Juan Jesus [6, 8, 7]
Total Authors: 12
Affiliation:
[1] Dante Pazzanese Inst Cardiol, Dept Hypertens & Nephrol, BR-04012909 Sao Paulo - Brazil
[2] Dante Pazzanese Inst Cardiol, Dept Teleelectrocardiog, BR-04012909 Sao Paulo - Brazil
[3] Hosp Gen Univ Gregorio Maranon, Nephrol Unit, Madrid - Spain
[4] Dante Pazzanese Inst Cardiol, Dept Echocardiog, BR-04012909 Sao Paulo - Brazil
[5] Dante Pazzanese Inst Cardiol, Dept Nutr, BR-04012909 Sao Paulo - Brazil
[6] Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm - Sweden
[7] Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum, Stockholm - Sweden
[8] Karolinska Inst, Ctr Mol Med, Stockholm - Sweden
Total Affiliations: 8
Document type: Journal article
Source: JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION; v. 8, n. 5, p. 312-320, MAY 2014.
Web of Science Citations: 3
Abstract

The electrocardiographic (ECG) strain pattern (Strain) is a marker of left ventricular hypertrophy (LVH) severity that provides additional prognostic information beyond echocardiography (ECHO) in the community level. We sought to evaluate its clinical determinants and prognostic usefulness in chronic kidney disease (CKD) patients. We evaluated 284 non-dialysis-dependent patients with CKD stages 3 to 5 (mean age, 61 years {[}interquartile range, 53-67 years]; 62% men). Patients were followed for 23 months (range, 13-32 months) for cardiovascular (CV) events and/or death. Strain patients (n = 37; 13%) were using more antihypertensive drugs, had higher prevalence of peripheral vascular disease and smoking, and higher levels of C-reactive protein, cardiac troponin, and brain natriuretic peptide (BNP). The independent predictors of Strain were: left ventricular mass index (LVMI), BNP, and smoking. During follow-up, there were 44 cardiovascular events (fatal and non-fatal) and 22 non-CV deaths; and Strain was associated with a worse prognosis independently of LVMI. Adding Strain to a prognostic model of LVMI improved in 15% the risk discrimination for the composite endpoint and in 12% for the CV events. Strain associates with CV risk factors and adds prognostic information over and above that of ECHO-assessed LVMI. Its routine screening may allow early identification of high risk CKD patients. (C) 2014 American Society of Hypertension. All rights reserved. (AU)

FAPESP's process: 10/16593-2 - Association between traditional, novel and uremic related risk factors and morbidity/mortality (all-cause and cardiovascular) in chronic kidney disease patients
Grantee:Antonio Carlos Cordeiro Silva Júnior
Support Opportunities: Regular Research Grants