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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Use of N-methylene phosphonic chitosan to obtain an isoniazid prodrug

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Author(s):
Daniela Gonçales Rando [1] ; Carlos Alberto Brandt [2] ; Elizabeth Igne Ferreira [3]
Total Authors: 3
Affiliation:
[1] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Farmácia
[2] Instituto Butantan
[3] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Farmácia
Total Affiliations: 3
Document type: Journal article
Source: Revista Brasileira de Ciências Farmacêuticas; v. 40, n. 3, p. 334-344, 2004-09-00.
Abstract

Tuberculosis(TB) is one of the most neglected health problems and has been out of control in many areas of the world. Since new antituberculous alternatives, including controlled classical drug delivery systems, are urgently needed to face this serious situation, the purpose of the present work was the synthesis and characterization of a prolonged action prodrug of isoniazid. The N-methylene phosphonic chitosan (NMPC), a hydrosoluble derivative of chitosan was used as drug carrier. This analog, as well as its precursor, exhibits stimulatory activity on macrophages, host cells of Mycobacterium tuberculosis. Due to its hydrosolubility, it can be easily handled and intravenously administrated. The NMPC can be obtained by reaction of chitosan with phosphorous acid in presence of formaldehyde. Once synthesized, the coupling with isoniazid was carried out after two steps: functionalization of the drug with a succinic spacer group and activation of the succinyl isoniazid through the cyclic analog 1-(pyridine-4-carbonyl)-tetrahydro-pirydazin-3,6-dione. (AU)