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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of the chronic exercise on the circulating concentration of leptin and ghrelin in rats With diet-induced obesity

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Author(s):
Ricardo Eguchi [1] ; Nadia Carla Cheik [2] ; Lila Missae Oyama [3] ; Claudia Maria Oller do Nascimento [4] ; Marco Túlio de Mello [5] ; Sergio Tufik [6] ; Ana Dâmaso [7]
Total Authors: 7
Affiliation:
[1] UNIFESP. Departamento de Ciências da Saúde
[2] Centro Universitário do Triângulo
[3] UNIFESP. Departamento de Ciências da Saúde
[4] UNIFESP. Departamento de Fisiologia
[5] UNIFESP. CEPE. Departamento de Psicobiologia
[6] UNIFESP. Departamento de Psicobiologia
[7] UNIFESP. Departamento de Ciências da Saúde
Total Affiliations: 7
Document type: Journal article
Source: Revista Brasileira de Medicina do Esporte; v. 14, n. 3, p. 182-187, 2008-06-00.
Abstract

Obesity is becoming one of the biggest worldwide epidemics. Therefore, knowing its etiology and mechanisms that regulate its development is of great relevance for its treatment. Thus, the aim of the present study was to evaluate the effects of obesity induced by the palatable hyperlipidic diet and of the chronic physical activity in rats, on the adiposity and the serum concentration of regulating hormones of the energy balance (leptin and ghrelin). 32 male Wistar rats were divided in four groups: Sedentary fed with chow diet (SN), sedentary fed with cafeteria diet (SC), trained fed with chow diet (TN) and trained fed with cafeteria diet (TC). The cafeteria diet led to a significant increase of central (RET) and visceral (EPI) adiposity (p<0.05). Conversely,the exercise training minimized the effect of the cafeteria diet, diminishing the central and visceral adiposity. Leptin was also increased in the groups fed with the cafeteria diet, suggesting increase of the resistance to the action of this hormone. Chronic physical activity did not hinder the development of hyperleptinemia. Reduction in the serum ghrelin concentration was observed only in the normocaloric group. Therefore,it has been concluded that the quality of diet and the quantity of adipose tissue mass behaved as important regulators of the serum concentration of leptin and ghrelin, reinforcing the importance of a suitable diet and continuous physical activity in the maintenance of body weight in the combat to the deleterious effects of obesity. (AU)

FAPESP's process: 06/00684-3 - Orexigenic, anorexigenic, pro and pre-inflamatory factors: effects of a multidisciplinary program for weight reduction in obese adolescents
Grantee:Ana Raimunda Dâmaso
Support Opportunities: Regular Research Grants