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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Physico-chemical characterization of inclusion complex between hydroxymethylnitrofurazone and hydroxypropyl-beta-cyclodextrin

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Author(s):
Renato Grillo [1] ; Nathalie F. S. de Melo [2] ; Leonardo Fernandes Fraceto [3] ; Charles L. Brito [4] ; Gustavo H. G. Trossini [5] ; Carla M. S. Menezes [6] ; Elizabeth Igne Ferreira [7] ; Carolina Morales Moraes [8]
Total Authors: 8
Affiliation:
[1] Universidade Estadual Paulista Júlio de Mesquita Filho. Departamento de Engenharia Ambiental - Brasil
[2] Universidade Estadual Paulista Júlio de Mesquita Filho. Departamento de Engenharia Ambiental - Brasil
[3] Universidade Estadual Paulista Júlio de Mesquita Filho. Departamento de Engenharia Ambiental - Brasil
[4] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas - Brasil
[5] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas - Brasil
[6] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas - Brasil
[7] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas - Brasil
[8] Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Bioquímica - Brasil
Total Affiliations: 8
Document type: Journal article
Source: Química Nova; v. 31, n. 2, p. 290-295, 2008-00-00.
Abstract

Hydroxymethylnitrofurazone (NFOH) is a prodrug that is active against Trypanosoma cruzi. It however presents low solubility and high toxicity. Hydroxypropyl-beta-cyclodextrin (HP-beta-CD) can be used as a drug-delivery system for NFOH modifying its physico-chemical properties. The aim of this work is to characterize the inclusion complex between NFOH and HP-beta-CD. The rate of NFOH release decreases after complexation and thermodynamic parameters from the solubility isotherm studies revealed that a stable complex is formed (deltaGº= 1.7 kJ/mol). This study focuses on the physico-chemical characterization of a drug-delivery formulation that comes out as a potentially new therapeutic option for Chagas disease treatment. (AU)

FAPESP's process: 05/03045-9 - Development of inclusion complexes between antichagasic compounds and cyclodextrins
Grantee:Leonardo Fernandes Fraceto
Support Opportunities: Regular Research Grants