| Full text | |
| Author(s): |
C.G. Machado
;
R.T. Calado
;
A.B. Garcia
;
R.P. Falcão
Total Authors: 4
|
| Document type: | Journal article |
| Source: | Brazilian Journal of Medical and Biological Research; v. 36, n. 12, p. 1653-1657, Dez. 2003. |
| Abstract | |
The multidrug resistance P-glycoprotein is a transmembrane efflux pump expressed by lymphocytes and is involved in their cytolytic activity. In the present study, we investigated the age-related changes of P-glycoprotein function in normal peripheral blood lymphocytes. Blood samples from 90 normal volunteers (age range, 0 to 86 years) were analyzed. P-glycoprotein function was assessed by the flow cytometric rhodamine 123 assay. P-glycoprotein function was highest in cord blood and progressively declined with age in peripheral blood T CD4+ and CD8+ cells. In contrast, P-glycoprotein function did not vary with age in CD19+ B or CD16+CD56+ natural killer cells. These data suggest that the decline in P-glycoprotein function in T CD4+ and CD8+ lymphocytes as a function of age may contribute to the decrease in T cell cytolytic activity with aging. (AU) | |
| FAPESP's process: | 98/14247-6 - Center for Research on Cell-Based Therapy |
| Grantee: | Marco Antonio Zago |
| Support type: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |