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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Neuronal plasticity associated with mesial temporal lobe epilepsy: insights form human and animal model studies

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Author(s):
Flávia Araujo Guedes ; Orfa Yineth Galvis-Alonso ; João Pereira Leite
Total Authors: 3
Document type: Journal article
Source: Journal of Epilepsy and Clinical Neurophysiology; v. 12, n. 1, p. 10-17, Mar. 2006.
Abstract

Temporal lobe epilepsy (TLE), the most frequent type of focal epilepsy in adults, is characterized by resistance to pharmacological treatment, progressive hipocampal neuronal loss and impairment of cognitive and neuropsychological performances. Studies with human specimens and experimental animal models have demonstrated exuberant and dynamic neuronal plasticity phenomena in the hipocampal formation associated with TLE. The study of these phenomena is fundamental for the definition of the genesis and progression mechanisms of epilepsy and for the development of better therapeutic strategies than those current available. In this article, we review neuronal and glial plastic alterations as neuronal death and birth, dendritic spine formation, axonal sprouting, gliosis and gap junction establishment and their role in the pathophysiology of TLE. (AU)

FAPESP's process: 05/56447-7 - Research through images from high field magnetic resonance aimed at studies in humans
Grantee:João Pereira Leite
Support type: Inter-institutional Cooperation in Support of Brain Research (CINAPCE) - Thematic Grants