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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Review- Alternatives for the separation of drug enantiomers: ibuprofen as a model compound

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Author(s):
P. O. Carvalho [1] ; Q. B. Cass [2] ; S. A. Calafatti [3] ; F. J. Contesini [4] ; R. Bizaco [5]
Total Authors: 5
Affiliation:
[1] Universidade São Francisco. Faculdade de Farmácia - Brasil
[2] Universidade Federal de São Carlos. Departamento de Química - Brasil
[3] Universidade São Francisco. Unidade Integrada de Farmacologia e Gastroenterologia Clínica - Brasil
[4] Universidade São Francisco. Faculdade de Farmácia - Brasil
[5] Universidade São Francisco. Faculdade de Farmácia - Brasil
Total Affiliations: 5
Document type: Journal article
Source: Brazilian Journal of Chemical Engineering; v. 23, n. 3, p. 291-300, 2006-09-00.
Abstract

Given the inherent dangers associated with racemic pharmaceuticals, exhaustive studies of techniques designed to separate enantiomers have been conducted. This paper reports a brief review of the different physical, chemical, and enzymatic methods used for the enantiomeric separation of rac-ibuprofen. The possible contribution of each technique to the preparation of enantiomerically pure drugs is reviewed in the context of competitive approaches that depend on the scale of application, with special emphasis on the recent progress achieved in this particular area. (AU)