Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae)

Author(s)

Fernando Rogério Pavan ^[1] ; Clarice Queico Fujimura Leite ^[2] ; Roberta Gomes Coelho ^[3] ; Isabel Duarte Coutinho ^[4] ; Neli Kika Honda ^[5] ; Claudia Andréa Lima Cardoso ^[6] ; Wagner Vilegas ^[7] ; Sergio Roberto de Andrade Leite ^[8] ; Daisy Nakamura Sato ^[9]

Affiliation

^[1] Universidade Estadual Paulista. Faculdade de Ciências Farmacêuticas. Departamento de Ciências Biológicas - Brasil

^[2] Universidade Estadual Paulista. Faculdade de Ciências Farmacêuticas. Departamento de Ciências Biológicas - Brasil

^[3] Universidade Federal de Mato Grosso do Sul. Departamento de Química - Brasil

^[4] Universidade Federal de Mato Grosso do Sul. Departamento de Química - Brasil

^[5] Universidade Federal de Mato Grosso do Sul. Departamento de Química - Brasil

^[6] Universidade Federal de Mato Grosso do Sul. Curso de Química - Brasil

^[7] Universidade Estadual Paulista. Instituto de Química. Departamento de Química - Brasil

^[8] Universidade Estadual Paulista. Instituto de Química. Departamento de Química - Brasil

^[9] Instituto Adolfo Lutz de Ribeirão Preto - Brasil

• Document type: Journal article
• Source: Química Nova; v. 32, n. 5, p. 1222-1226, 2009-00-00.

Abstract

The anti-Mycobacterium tuberculosis activity of Campomanesia adamantium fruits extracts were evaluated. Six compounds, identified as flavanones and chalcones were quantified by HPLC-DAD-UV. Promising antitubercular activity was observed with ethyl acetate extract (MIC 62.5 µg/mL) and their fractions (MIC values ranging from 39 to above 250 µg/mL). The better MIC result of 39 µg/mL was associated with two fractions that contain bigger amounts of 5,7-dihydroxy-6, 8-di-C-methylflavanone and 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone. These compounds exhibited MICs >250 and 62.5 µg/mL, respectively, while their mixtures showed values ranging from 62.5 to 7.8 µg/mL, demonstrating a synergism between them. (AU)

• FAPESP's process: 08/10390-2 - Determination of pre-clinical profile in vitro and in vivo anti-tuberculosis activity of ruthenium(II)phosphine / picolinate complexes
• Grantee: Fernando Rogério Pavan
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 02/05503-6 - Sustainable use of the Brazilian biodiversity: chemical and pharmacological prospection on higher plants
• Grantee: Wagner Vilegas
• Support Opportunities: BIOTA-FAPESP Program - Thematic Grants