Wound-healing and benzodiazepines: does sleep play a role in this relationship?

Author(s)

Egydio, Flavia ^[1] ; Pires, Gabriel Natan ^[1] ; Tufik, Sergio ^[1] ; Andersen, Monica Levy ^[1]

Affiliation

^[1] Univ Fed Sao Paulo UNIFESP, Dept Psicobiol, Sao Paulo - Brazil

• Document type: Journal article
• Source: Clinics; v. 67, n. 7, p. 827-830, 2012.
• Web of Science Citations: 5

Abstract

Patients who have suffered burns frequently experience psychological consequences, among which anxiety disorders are prominent. Benzodiazepines are commonly administered to treat these symptoms. The effects of benzodiazepines on healing may not be direct but rather are modulated by alterations of the sleep architecture. This hypothesis is supported by studies that demonstrate the effects of benzodiazepines on the immune system and the inflammatory profile under both normal sleep conditions and during sleep deprivation, particularly rapid eye movement sleep deprivation. (AU)

• FAPESP's process: 10/14768-0 - EFFECT OF SLEEP RESTRICTION DURING PREGNANCY ON MATERNAL BEHAVIOR IN RATS
• Grantee: Gabriel Natan de Souza Pires
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 98/14303-3 - Center for Sleep Studies
• Grantee: Sergio Tufik
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 11/14462-0 - EFFECTS OF CHRONIC MORPHINE ADMINISTRATION IN WOUND HEALING OF SLEEP DEPRIVED MICE
• Grantee: Flávia de Mattos Egydio
• Support Opportunities: Scholarships in Brazil - Master