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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Wound-healing and benzodiazepines: does sleep play a role in this relationship?

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Egydio, Flavia [1] ; Pires, Gabriel Natan [1] ; Tufik, Sergio [1] ; Andersen, Monica Levy [1]
Total Authors: 4
[1] Univ Fed Sao Paulo UNIFESP, Dept Psicobiol, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Source: Clinics; v. 67, n. 7, p. 827-830, 2012.
Web of Science Citations: 5

Patients who have suffered burns frequently experience psychological consequences, among which anxiety disorders are prominent. Benzodiazepines are commonly administered to treat these symptoms. The effects of benzodiazepines on healing may not be direct but rather are modulated by alterations of the sleep architecture. This hypothesis is supported by studies that demonstrate the effects of benzodiazepines on the immune system and the inflammatory profile under both normal sleep conditions and during sleep deprivation, particularly rapid eye movement sleep deprivation. (AU)

FAPESP's process: 98/14303-3 - Center for Sleep Studies
Grantee:Sergio Tufik
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 11/14462-0 - Effects of chronic morphine administration in wound healing of sleep deprived mice
Grantee:Flávia de Mattos Egydio
Support type: Scholarships in Brazil - Master
FAPESP's process: 10/14768-0 - Effect of sleep restriction during pregnancy on maternal behavior in rats
Grantee:Gabriel Natan de Souza Pires
Support type: Scholarships in Brazil - Master