Relationship between variants of the leptin gene and obesity and metabolic biomarkers in Brazilian individuals

Author(s)

Hinuy, Hamilton M. ; Hirata, Mario H. ; Sampaio, Marcelo F. ^[1] ; Armaganijan, Dikran ^[1] ; Arazi, Simone Sorkin ; Salazar, Luis A. ^[2] ; Hirata, Rosario D. C. ^[3]

Affiliation

^[1] IDPC, Sao Paulo - Brazil

^[2] Univ La Frontera, Fac Med, Temuco - Chile

^[3] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, BR-05508900 Sao Paulo - Brazil

• Document type: Journal article
• Source: Arquivos Brasileiros de Endocrinologia e Metabologia; v. 54, n. 3, p. 282-288, APR 2010.
• Web of Science Citations: 17

Abstract

Objective: The relationship between variants of the leptin gene (LEP) and obesity and metabolic biomarkers was investigated in Brazilian individuals. Subjects and methods: One-hundred-ten obese (BMI > 30 kg/m(2)) and 100 non-obese individuals (145 women and 65 men, aged 49 14 years) were randomly selected. Plasma leptin, glycemia, serum lipid measurements and LEP -2548G>A and 3'HVR polymorphisms were analyzed. Results: The LEP -2548GG genotype was associated with a 2.2% and 2.0% increase in BMI (p = 0.009) and plasma leptin (p = 0.031), respectively. 3'HVR I/II (classes I/I+I/II) genotypes contributed with 1.8% of BMI values (p = 0.046). LEPI/G combined genotypes (I/IGG, I/IGA and I/IIGG) were associated with obesity, and increased BMI, waist circumference, leptin and triglycerides (p < 0.05). These relationships were found in women (p < 0.05) but not in men. LEP I/G combined genotypes were not associated with hypertension, hyperglycemia, dyslipidemia and coronary artery disease. Conclusions: LEP I/G combined genotypes are associated with obesity-related metabolic biomarkers and phenotype in a gender-dependent manner. Arq Bras Endocrinol Metab. 2010;54(3):282-8 (AU)

• FAPESP's process: 06/04994-7 - Leptin and leptin receptor variants: influence on body composition and plasma markers of obesity
• Grantee: Rosario Dominguez Crespo Hirata
• Support Opportunities: Regular Research Grants