In vitro schistosomicidal effects of the essential oil of Tagetes erecta

Author(s):Show less -

Tonuci, Ligia R. S. ^[1] ; de Melo, Nathalya I. ^[1] ; Dias, Herbert J. ^[1] ; Wakabayashi, Kamila A. L. ^[1] ; Aguiar, Gabriela P. ^[1] ; Aguiar, Daniela P. ^[1] ; Mantovani, Andre L. L. ^[1] ; Ramos, Rafael C. ^[1] ; Groppo, Milton ^[2] ; Rodrigues, Vanderlei ^[3] ; Veneziani, Rodrigo C. S. ^[1] ; Cunha, Wilson R. ^[1] ; da Silva Filho, Ademar A. ^[4] ; Magalhaes, Lizandra G. ^[1] ; Crotti, Antonio E. M. ^[1]

Affiliation

^[1] Univ Franca, BR-14404600 Franca, SP - Brazil

^[2] Univ Sao Paulo, Dept Biol, Fac Filosofia Ciencias & Letras Ribeirao Preto, BR-05508 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept Imunol, Fac Med Ribeirao Preto, BR-05508 Sao Paulo - Brazil

^[4] Univ Fed Juiz Fora, Fac Farm, Juiz De Fora - Brazil

• Document type: Journal article
• Source: REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 22, n. 1, p. 88-93, JAN-FEB 2012.
• Web of Science Citations: 19

Abstract

The in vitro schistosomicidal effects of the essential oil obtained from Tagetes erecta L. Asteraceae, leaves (TE-EO) collected in Brazil against Schistosoma mansoni worms are reported in this paper. The oil caused a significant decrease in the motor activity at 50 µg/mL as minimal concentration after 24 h. This oil also caused death of all the parasites and the separation of coupled pairs into individual male and female at 100 µg/mL after 24 h. The viability of adult worm groups treated with the TE-EO at 100 µg/mL was similar to that of groups treated with praziquantel (positive control). In addition, the oil promoted the inhibition of eggs development at all the tested concentrations. These data indicate that the TE-EO could be considered as a promising source for the development of new schistosomicidal agents. (AU)