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Potential of crude extracts, essential oil and pure compounds obtained from Tagetes patula l. (Asteraceae) as botanical biopesticide against Rhipicephalus (Boophilus) microplus, Haemonchus contortus and Cimex lectularis

Grant number: 13/03493-8
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): June 01, 2013
Effective date (End): May 31, 2017
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:Maysa Furlan
Grantee:Flávio Augusto Sanches Politi
Home Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Associated research grant:13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery, AP.CEPID

Abstract

The tick Rhipicephalus (Boophilus) microplus (Canestrini, 1887) is a health problem and cause great damage to livestock. The dependence of few chemical acaricides bases available on the market, combined with its wrong use, led to widespread dispersal of resistance in the population of this ticks, reaching up to the point that most commercial products does not exhibit the expected or necessary efficacy for parasite control. With this background, it is relevant the increase in the number of scientific works that seek to detectnew active compounds acting on parasites, isolated from plants, fungi or other organisms. Tagetes patula (Latreille, 1806) (Asteraceae) is an excellent plant species matrix in search of natural insecticides since it is a strong-scented bushy annual, widespread throughout the world. Several studies highlight its repellent and insecticide potential. Although references about their chemical constitution, there are no studies that show the biocidal effect of compounds isolated from their plant extracts. Thus, this project aims to isolate, identify and evaluate the action of pure substances and crude plant extractives against parasites of outstanding economic and social importance, like the cattle tick Rh. (Boophilus) microplus, the gastrointestinal nematode of sheep and goats Haemonchus contortus and bedbug Cimex lectularis. Furthermore, in order to ensure the safety of using these compounds it is intended to perform the tests of acute oral toxicity and skin sensitization.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANCHES POLITI, FLAVIO AUGUSTO; FANTATTO, RAFAELA REGINA; DA SILVA, ALEXANDER ALVES; MORO, ISABELA JACOB; SAMPIERI, BRUNO RODRIGUES; CAMARGO-MATHIAS, MARIA IZABEL; FIGUEIREDO, AMANDA; DE SOUZA CHAGAS, ANA CAROLINA; FURLAN, MAYSA. Evaluation of Tagetes patula (Asteraceae) as an ecological alternative in the search for natural control of the cattle tick Rhipicephalus (Boophilus) microplus (Acari: Ixodidae). Experimental and Applied Acarology, v. 77, n. 4, p. 601-618, APR 2019. Web of Science Citations: 0.
SANCHES POLITI, FLAVIO AUGUSTO; SOUZA JUNIOR, AMAURI ALVES; FANTATTO, RAFAELA REGINA; LINHARI RODRIGUES PIETRO, ROSEMEIRE CRISTINA; BARIONI JUNIOR, WALDOMIRO; RABELO, MARCIO DIAS; BIZZO, HUMBERTO RIBEIRO; DE SOUZA CHAGAS, ANA CAROLINA; FURLAN, MAYSA. Chemical Composition and In vitro Anthelmintic Activity of Extracts of Tagetes patula Against a Multidrug-Resistant Isolate of Haemonchus contortus. CHEMISTRY & BIODIVERSITY, v. 15, n. 2 FEB 2018. Web of Science Citations: 3.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.