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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A comparative study of pentoxifylline effects in adult and aged rats submitted to lung dysfunction by thermal injury

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Author(s):
Ramallo, Bianca Trovello [1] ; Loureco, Elizete [2] ; Cruz, Renata Harumi [3] ; Almeida, Jacqueline Camargo [4] ; Taha, Murched Omar [5] ; Okochi Alves Silva, Priscilla Yuri [6] ; Oliveira-Junior, Itamar Souza [7]
Total Authors: 7
Affiliation:
[1] Univ Fed Sao Paulo. Dept Surg
[2] Univ Fed Sao Paulo. Div Anesthesiol Pain & Intens Therapy
[3] Univ Fed Sao Paulo. Div Anesthesiol Pain & Intens Therapy
[4] Univ Fed Sao Paulo. Div Anesthesiol Pain & Intens Therapy
[5] Univ Fed Sao Paulo. Dept Surg
[6] Univ Fed Sao Paulo. Div Anesthesiol Pain & Intens Therapy
[7] Univ Fed Sao Paulo. Div Anesthesiol Pain & Intens Therapy
Total Affiliations: 7
Document type: Journal article
Source: Acta Cirurgica Brasileira; v. 28, n. 2, p. 154-159, FEB 2013.
Web of Science Citations: 4
Abstract

PURPOSE: To investigate the protective effects of pentoxifylline against lung injury observed after dorsal scald in aged animals. METHODS: Adult (eight months old) and aged (20 months old) rats were subjected to thermal injury or sham procedure. The six hours post-trauma animals received pentoxifylline and after 24 hours were euthanatized and lung tissue samples collectedted. The bronchoalveolar lavage fluid was evaluated for total protein content and tumor necrosis factor-alpha cytokine. Malondialdehyde and myeloperoxidase activety in the lung homogenate were measured and a histological lung examination was undertaken. RESULTS: Burn injury induced oxidative stress in lung homogenate was higher in elderly-burned rats compared to adult-burned rats (p<0.001). Total protein and cytokine in bronchoalveolar lavage increased in the elderly-burned group when compared to the adult-burned group (p<0.001). All parameters decreased in bolth groups treated with pentoxifylline (p<0.05). CONCLUSIONS: The injury was augmented in elderly rats when compared to adult rats. Damage was reduced with the use of pentoxifylline, however further studies are needed to evaluate the dose-response of the drug. (AU)