(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)
Discrimination of bile acids by the rainbow trout olfactory system: Evidence as potential pheromone
Giaquinto, Percilia C.
Hara, Toshiaki J.
Total Authors: 2
 Univ Estadual Paulista. Inst Biol
 Fisheries & Oceans Canada. Inst Freshwater
Total Affiliations: 2
Web of Science Citations:
Electro-olfactogram recording was used to determine whether the olfactory epithelium of adult rainbow trout is specifically sensitive to bile acids, some of which have been hypothesized to function as pheromones. Of 38 bile acids that had been pre-screened for olfactory activity, 6 were selected. The rainbow trout-specific bile acids, taurocholic acid (TCA), and taurolithocholic acid 3-sulfate (TLS) were the most potent compounds tested. TLS had a distinctive dose-response curve. Cross-adaptation experiments demonstrated that sensitivity to bile acids is attributable to at least 3 independent classes of olfactory receptor sites. Our data suggest that bile acids are discriminated by olfaction in rainbow trout, supporting the possibility that these compounds function as pheromones. (AU)