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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Coronary artery plaque burden and calcium scores in healthy men adhering to long-term wine drinking or alcohol abstinence

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Author(s):
P.L. da Luz [1] ; S. Coimbra [1] ; D. Favarato [1] ; C. Albuquerque [1] ; R.I. Mochiduky [5] ; C.E. Rochitte [3] ; E. Hojaij [4] ; C.R.L. Gonsalves [5] ; F.R. Laurindo [6]
Total Authors: 9
Affiliation:
[1] Univ Sao Paulo, Fac Med, Inst Coracao Incor, Div Cardiol Clin, BR-05403000 Sao Paulo - Brazil
[2] Universidade de São Paulo. Faculdade de Medicina. Instituto do Coração (Incor) - Brasil
[3] Univ Sao Paulo, Fac Med, Inst Coracao Incor, Div Radiol, BR-05403000 Sao Paulo - Brazil
[4] Univ Sao Paulo, Fac Med, Inst Coracao Incor, Serv Psicol, BR-05403000 Sao Paulo - Brazil
[5] Univ Sao Paulo, Fac Med, Inst Coracao Incor, Serv Nutr, BR-05403000 Sao Paulo - Brazil
[6] Univ Sao Paulo, Fac Med, Inst Coracao Incor, Lab Biol Vasc, BR-05403000 Sao Paulo - Brazil
Total Affiliations: 6
Document type: Journal article
Source: Brazilian Journal of Medical and Biological Research; v. 47, n. 8, p. 697-705, 2014-07-04.
Abstract

Observational studies suggest there are clinical benefits to moderate red wine (RW) consumption. However, the effects on coronary vasculature and overall lifestyle are unclear. We investigated whether a lifestyle of regular long-term RW consumption is associated with changes in coronary plaque burden, calcium score, carotid intima/media thickness, endothelial function, and metabolic variables, compared with alcohol abstinence. Healthy volunteers were evaluated by coronary computed tomography angiography (CTA) as well as carotid and brachial artery ultrasound. Nutritional status, psychological status, and metabolic variables were assessed. The study included 101 drinkers [aged 58.9±7.3 years (means±SD)], from wine brotherhoods, and 104 abstainers, from Anglican, Evangelical and Catholic churches both in the city of São Paulo, Brazil. No significant differences in demographics were noted. Lesion prevalence per patient assessed by coronary CTA and classified as absent (0), 1-25, 26-49, and ≥50% stenosis was similar between groups. When analyzed by individual arteries, i.e., left anterior descending, circumflex, and right coronary, prevalence was also not different. On the other hand, calcium scores were higher among drinkers than abstainers (144.4±362.2 vs 122.0±370.3; P<0.01). However, drinkers reported less history of diabetes and exercised more. RW drinkers consumed 2127.9±387.7 kcal/day while abstainers consumed 1836.0±305.0 (P<0.0001). HDL cholesterol was significantly higher among drinkers compared to abstainers (46.9±10.9 vs 39.5±9.0 mg/dL; P<0.001), while fasting plasma glucose was lower (97.6±18.2 vs 118.4±29.6 mg/dL; P<0.02). Liver enzymes were normal in both groups. In conclusion, long-term wine drinkers displayed a similar plaque burden but greater calcium score than abstainers, despite a more atherogenic diet, and the mechanisms for the increased calcium scores in the former remain speculative. (AU)

FAPESP's process: 12/00329-0 - Effects of physical training and red wine ingestion upon cognitive function of healthy individuals
Grantee:Protasio Lemos da Luz
Support Opportunities: Regular Research Grants