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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Evaluation of neurotransmitter receptor gene expression identifies GABA receptor changes: A follow-up study in antipsychotic-naive patients with first-episode psychosis

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Author(s):
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Ota, Vanessa Kiyomi [1, 2] ; Noto, Cristiano [3, 2, 4] ; Gadelha, Ary [2, 3] ; Santoro, Marcos Leite [1, 2] ; Ortiz, Bruno Bertolucci [3] ; Andrade, Elvis Henrique [3] ; Tasso, Brazilio Carvalho [4] ; Nery Spindola, Leticia Maria [1, 2] ; Silva, Patricia Natalia [3, 1, 2] ; Abilio, Vanessa Costhek [3, 2, 5] ; Cardoso Smith, Marilia de Arruda [1] ; Sato, Joao Ricardo [2, 6] ; Brietzke, Elisa [2, 3] ; Cordeiro, Quirino [3, 4] ; Bressan, Rodrigo Affonseca [3, 2] ; Belangero, Sintia Iole [3, 1, 2]
Total Authors: 16
Affiliation:
[1] Univ Fed Sao Paulo UNIFESP, Dept Morphol & Genet, Div Genet, BR-04023900 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo UNIFESP, LiNC Interdisciplinary Lab Clin Neurosci, BR-05039032 Sao Paulo - Brazil
[3] Univ Fed Sao Paulo UNIFESP, Dept Psychiat, Sao Paulo - Brazil
[4] ISCMSP, Dept Psychiat, Sao Paulo - Brazil
[5] Univ Fed Sao Paulo UNIFESP, Dept Pharmacol, Sao Paulo - Brazil
[6] Univ Fed ABC, Ctr Math Computat & Cognit, Santo Andre - Brazil
Total Affiliations: 6
Document type: Journal article
Source: JOURNAL OF PSYCHIATRIC RESEARCH; v. 56, p. 130-136, SEP 2014.
Web of Science Citations: 12
Abstract

A study of the gene expression levels in the blood of individuals with schizophrenia in the beginning of the disease, such as first-episode psychosis (FEP), is useful to detect gene expression changes in this disorder in response to treatment. Although a large number of genetic studies on schizophrenia have been conducted, little is known about the effects of antipsychotic treatment on gene expression. The aim of the present study was to examine differences in the gene expression in the blood of antipsychotic-naive FEP patients before and after risperidone treatment (N = 44) and also to verify the correlation with treatment response. In addition, we determined the correlations between differentially expressed genes and clinical variables. The expression of 40 neurotransmitter and neurodevelopment-associated genes was assessed using the RT2 Profiler (TM) PCR Array. The results indicated that the GABRR2 gene was downregulated after risperidone treatment, but no genes were associated with response to treatment and clinical variables after Bonferroni correction. GABRR2 downregulation after treatment can both suggest an effect of risperidone treatment or processes related to disease progression, either not necessarily associated with the improvement of symptoms. Despite this change was observed in blood, this decrease in GABRR2 mRNA levels might be an effect of changes in GABA concentrations or other systems interplay consequently to D2 blockage induced by risperidone, for example. Thus, it is important to consider that antipsychotics or the progression of psychotic disorders might interfere with gene expression. (C) 2014 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 10/19176-3 - GENE EXPRESSION AND DNA METHYLATION ANALYSES IN DRUG-NAIVE FIRST EPISODE OF PSYCHOSIS PATIENTS
Grantee:Vanessa Kiyomi Ota Kuniyoshi
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 13/10498-6 - Machine learning in neuroimaging: development of methods and clinical applications in psychiatric disorders
Grantee:João Ricardo Sato
Support type: Regular Research Grants
FAPESP's process: 11/50740-5 - Prevention in schizophrenia and bipolar disorder from neuroscience to the community: a multiphase, multimodal and translational platform for research and intervention
Grantee:Rodrigo Affonseca Bressan
Support type: Research Projects - Thematic Grants
FAPESP's process: 10/08968-6 - INVESTIGATION OF GENETIC AND EPIGENETIC MARKERS: A TRANSLATIONAL APPROACH FOR SCHIZOPHRENIA TREATMENT
Grantee:Síntia Iole Nogueira Belangero
Support type: Regular Research Grants