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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Silver colloidal nanoparticle stability: influence on Candida biofilms formed on denture acrylic

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Author(s):
Monteiro, Douglas Roberto [1] ; Takamiya, Aline Satie [1] ; Feresin, Leonardo Perina [1] ; Gorup, Luiz Fernando [2] ; de Camargo, Emerson Rodrigues [2] ; Botazzo Delbem, Alberto Carlos [1] ; Henriques, Mariana [3] ; Barbosa, Debora Barros [4]
Total Authors: 8
Affiliation:
[1] Univ Estadual Paulista, Aracatuba Dent Sch, Dept Pediat Dent & Publ Hlth, BR-16015050 Aracatuba, SP - Brazil
[2] Univ Fed Sao Carlos, LIEC Dept Chem, BR-13560 Sao Carlos, SP - Brazil
[3] Univ Minho, Inst Biotechnol & Bioengn, Dept Biol Engn, Braga - Portugal
[4] Univ Estadual Paulista, Aracatuba Dent Sch, Dept Dent Mat & Prosthodont, BR-16015050 Aracatuba, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Medical Mycology; v. 52, n. 6, p. 627-635, AUG 2014.
Web of Science Citations: 6
Abstract

Our aim in this study was to evaluate how the chemical stability of silver nanoparticles (SNs) influences their efficacy against Candida albicans and C. glabrata biofilms. Several parameters of SN stability were tested, namely, temperature (50 degrees C, 70 degrees C, and 100 degrees C), pH (5.0 and 9.0), and time of contact (5 h and 24 h) with biofilms. The control was defined as SNs without temperature treatment, pH 7, and 24 h of contact. These colloidal suspensions at 54 mg/L were used to treat mature Candida biofilms (48 h) formed on acrylic. Their efficacy was determined by total biomass and colony-forming unit quantification. Data were analyzed using analysis of variance and the Bonferroni post hoc test (alpha = 0.05). The temperature and pH variations of SNs did not affect their efficacy against the viable cells of Candida biofilms (P > 0.05). Moreover, the treatment periods were not decisive in terms of the susceptibility of Candida biofilms to SNs. These findings provide an important advantage of SNs that may be useful in the treatment of Candida-associated denture stomatitis. (AU)

FAPESP's process: 09/15146-5 - Effect of silver nanoparticles on Candida spp. biofilm
Grantee:Douglas Roberto Monteiro
Support Opportunities: Scholarships in Brazil - Doctorate