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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Synthesis of functionalized N-triazolyl maleimides

Full text
Author(s):
Stefani, Helio A. [1] ; Ferreira, Fernando P. [2] ; Ali, Bakhat [1] ; Pimenta, Daniel C. [3]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farm, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Biofis, Sao Paulo - Brazil
[3] Inst Butantan, Lab Bioquim & Biofis, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Tetrahedron Letters; v. 55, n. 31, p. 4355-4358, JUL 30 2014.
Web of Science Citations: 7
Abstract

An easy and mild two-step one-pot reaction allowed the synthesis of functionalized N-triazolyl maleimide. Next, the addition of propargyl alcohol and propargyl amine to the N-acyliminium ion mediated by Lewis acid, In(OTf)(3), allowed the introduction of a second 1,2,3-triazol ring at position 5 of the amide. The products in both reactions were achieved in moderate to good yields. (C) 2014 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 12/00424-2 - Synthesis of small libraries using potassium Organotrifluoroborates in Suzuki-Miyaura reactions
Grantee:Helio Alexandre Stefani
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 12/17954-4 - Cyclization reaction of Acetyl- and Ethylpyrrolidin-2-one with Potassium Organotrifluoroborate Salts
Grantee:Bakhat Ali
Support Opportunities: Scholarships in Brazil - Post-Doctoral