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Synthesis of molecular fluorescent diarylmaleimide probes form the Heck-Matsuda reactions and their applications in biology and biochemistry

Grant number: 13/25613-5
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): June 01, 2014
Effective date (End): May 31, 2018
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal researcher:Carlos Roque Duarte Correia
Grantee:Michele Panciera
Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated scholarship(s):16/23055-3 - Novel marinoquinoline-based compounds for tuberculosis therapy: design, synthesis and structure-activity screening, BE.EP.PD


Based on previous studies carried out by the research group, this project aims at the synthesis of fluorescent maleimide probes for attachment to key proteins applying a low cost method. The probes will be prepared using a Heck-Matsuda reaction which employs arenediazonium salts and palladium as catalyst. This method has been proved highly effective in the construction of arylated maleic anhydrides and maleimides, which are also important structural moieties of some bioactive natural products, such as rebbecamicine displaying antitumor activity.The project is an ongoing on, and the its new aspects should strengthen many collaborations involving Prof. Correias lab and others in Brazil and abroad, such the one headed by Dr. Ludger Wessjohann, at Halle, Germany.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CAMPOS AGUIAR, ANNA CAROLINE; PANCIERA, MICHELE; SIMAO DOS SANTOS, ERIC FRANCISCO; SINGH, MANEESH KUMAR; GARCIA, MARIANA LOPES; DE SOUZA, GUILHERME EDUARDO; NAKABASHI, MYNA; COSTA, JOSE LUIZ; GARCIA, CELIA R. S.; OLIVA, GLAUCIUS; DUARTE CORREIA, CARLOS ROQUE; CARVALHO GUIDO, RAFAEL VICTORIO. Discovery of Marinoquinolines as Potent and Fast-Acting Plasmodium falciparum Inhibitors with in Vivo Activity. Journal of Medicinal Chemistry, v. 61, n. 13, p. 5547-5568, JUL 12 2018. Web of Science Citations: 7.

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