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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Whole-body magnetic resonance imaging in the assessment of muscular involvement in juvenile dermatomyositis/polymyositis patients

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Author(s):
Castro, T. C. M. [1] ; Lederman, H. [2] ; Terreri, M. T. [1] ; Caldana, W. I. [2] ; Zanoteli, E. [3] ; Hilario, M. O. E. [1]
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Paulo, Dept Paediat, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Radiol, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Med, Dept Neurol, BR-05508 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY; v. 43, n. 4, p. 329-333, 2014.
Web of Science Citations: 10
Abstract

Objectives: Our aim was to demonstrate the benefit of whole-body magnetic resonance imaging (WBMRI) as a diagnostic modality in the detection of muscle activity in juvenile dermatomyositis (JDM)/polymyositis (JPM) patients and to correlate these findings with clinical evaluation, laboratory examinations, nailfold capillaroscopy (NFC), and muscle biopsy. Method: Thirty-four patients aged 5.5 to 18.9 years with a diagnosis of JDM/JPM were prospectively evaluated using clinical examination, muscle enzyme determination, the Childhood Myositis Assessment Scale (CMAS), Disease Activity Score (DAS), Manual Muscle Testing (MMT), NFC, and WBMRI. An open muscle biopsy was performed if muscle disease activity was detected on WBMRI. Results: Disease activity was detected in WBMRI in four (11.7%) patients and confirmed by muscle biopsy. All four patients had elevation of at least one muscle enzyme and NFC showed scleroderma patterns in these patients. Conclusions: WBMRI allows us to evaluate the extent and symmetry of muscle disease and inflammatory activity. NFC is an important additional examination to assess disease activity. (AU)