Kinin B-2 receptor deletion and blockage ameliorates cisplatin-induced acute renal injury

Author(s)

Estrela, Gabriel R. ^{[1, 2]} ; Wasinski, Frederick ^{[1, 2]} ; Bacurau, Reury F. ^[3] ; Malheiros, Denise M. A. C. ^[4] ; Camara, Niels O. S. ^[5] ; Araujo, Ronaldo C. ^[1]

Affiliation

^[1] Univ Fed Sao Paulo, Dept Biophys, BR-04039032 Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Div Nephrol, Dept Med, BR-04023900 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Arts Sci & Humanities, BR-03828000 Sao Paulo - Brazil

^[4] Univ Sao Paulo, Dept Clin Med, BR-05403000 Sao Paulo - Brazil

^[5] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Lab Transplantat Immunobiol, BR-05508900 Sao Paulo - Brazil

• Document type: Journal article
• Source: International Immunopharmacology; v. 22, n. 1, p. 115-119, SEP 2014.
• Web of Science Citations: 4

Abstract

Cisplatin treatment has been adopted in some chemotherapies; however, this drug can induce acute kidney injury due its ability to negatively affect renal function, augment serum levels of creatinine and urea, increase the acute tubular necrosis score and up-regulate cytokines (e.g., IL-1 beta and TNF-alpha). The kinin B2 receptor has been associated with the inflammation process, as well as the regulation of cytokine expression, and its deletion resulted in an improvement in the diabetic nephropathy status. To examine the role of the kinin B2 receptor in cisplatin-induced acute kidney injury, kinin B2 receptor knockout mice were challenged with cisplatin. Additionally, WT mice were treated with a B2 receptor antagonist after cisplatin administration. B2 receptor-deficient mice were less sensitive to this drug than the WT mice, as shown by reduced weight loss, better preservation of kidney function, down regulation of inflammatory cytokines and less acute tubular necrosis. Moreover, treatment with the kinin B2 receptor antagonist effectively reduced the levels of serum creatinine and blood urea after cisplatin administration. Thus, our data suggest that the kinin B2 receptor is involved in cisplatin-induced acute kidney injury by mediating the necrotic process and the expression of inflammatory cytokines, thus resulting in declined renal function. These results highlight the kinin B2 receptor antagonist treatment in amelioration of nephrotoxicity induced by cisplatin therapy. (C) 2014 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 11/03528-0 - Effect on inflammation modulation of adipose tissue of obese mice by physical training
• Grantee: Ronaldo de Carvalho Araújo
• Support type: Regular Research Grants