(In) Consistencies in Responses to Sodium Bicarbonate Supplementation: A Randomised, Repeated Measures, Counterbalanced and Double-Blind Study

Autor(es)

de Araujo Dias, Gabriela Froio ^[1] ; Silva, Vinicius da Eira ^[1] ; Painelli, Vitor de Salles ^[1] ; Sale, Craig ^[2] ; Artioli, Guilherme Giannini ^[1] ; Gualano, Bruno ^[1] ; Saunders, Bryan ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Phys Educ & Sport, Lab Appl Nutr & Metab, Sao Paulo - Brazil

^[2] Nottingham Trent Univ, Sch Sci & Technol, Sport Hlth & Performance Enhancement SHAPE Res Gr, Nottingham - England

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 10, n. 11 NOV 17 2015.
• Citações Web of Science: 11

Resumo

Objectives Intervention studies do not account for high within-individual variation potentially compromising the magnitude of an effect. Repeat administration of a treatment allows quantification of individual responses and determination of the consistency of responses. We determined the consistency of metabolic and exercise responses following repeated administration of sodium bicarbonate (SB). Design and Methods 15 physically active males (age 25 +/- 4 y; body mass 76.0 +/- 7.3 kg; height 1.77 +/- 0.05 m) completed six cycling capacity tests at 110% of maximum power output (CCT110%) following ingestion of either 0.3 g.kg(-1)BM of SB (4 trials) or placebo (PL, 2 trials). Blood pH, bicarbonate, base excess and lactate were determined at baseline, pre-exercise, post-exercise and 5-min post-exercise. Total work done (TWD) was recorded as the exercise outcome. Results SB supplementation increased blood pH, bicarbonate and base excess prior to every trial (all p <= 0.001); absolute changes in pH, bicarbonate and base excess from baseline to preexercise were similar in all SB trials (all p > 0.05). Blood lactate was elevated following exercise in all trials (p <= 0.001), and was higher in some, but not all, SB trials compared to PL. TWD was not significantly improved with SB vs. PL in any trial (SB1: +3.6%; SB2 + 0.3%; SB3: +2.1%; SB4: +6.7%; all p > 0.05), although magnitude-based inferences suggested a 93% likely improvement in SB4. Individual analysis showed ten participants improved in at least one SB trial above the normal variation of the test although five improved in none. Conclusions The mechanism for improved exercise with SB was consistently in place prior to exercise, although this only resulted in a likely improvement in one trial. SB does not consistently improve high intensity cycling capacity, with results suggesting that caution should be taken when interpreting the results from single trials as to the efficacy of SB supplementation. (AU)

• Processo FAPESP: 14/11948-8 - Vida sem carnosina: desenvolvimento e caracterização de um modelo de rato nocaute para estudo do papel fisiológico da carnosina e suas implicações para o exercício físico e metabolismo muscular
• Beneficiário: Guilherme Giannini Artioli
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 11/19513-2 - Efeitos da Suplementação Crônica de Beta-Alanina Combinada ou não à Ingestão Aguda de Bicarbonato de Sódio sobre a Concentração Pico de Carnosina, o "Washout" de Carnosina e o Desempenho em Exercício Intenso.
• Beneficiário: Bryan Saunders
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/14746-4 - Metabolismo da carnosina no músculo esquelético: um estudo de múltiplas abordagens
• Beneficiário: Bruno Gualano
• Modalidade de apoio: Auxílio à Pesquisa - Temático
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• Beneficiário: Vitor de Salles Painelli
• Modalidade de apoio: Bolsas no Brasil - Doutorado