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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

(In) Consistencies in Responses to Sodium Bicarbonate Supplementation: A Randomised, Repeated Measures, Counterbalanced and Double-Blind Study

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de Araujo Dias, Gabriela Froio [1] ; Silva, Vinicius da Eira [1] ; Painelli, Vitor de Salles [1] ; Sale, Craig [2] ; Artioli, Guilherme Giannini [1] ; Gualano, Bruno [1] ; Saunders, Bryan [1]
Total Authors: 7
[1] Univ Sao Paulo, Sch Phys Educ & Sport, Lab Appl Nutr & Metab, Sao Paulo - Brazil
[2] Nottingham Trent Univ, Sch Sci & Technol, Sport Hlth & Performance Enhancement SHAPE Res Gr, Nottingham - England
Total Affiliations: 2
Document type: Journal article
Source: PLoS One; v. 10, n. 11 NOV 17 2015.
Web of Science Citations: 11

Objectives Intervention studies do not account for high within-individual variation potentially compromising the magnitude of an effect. Repeat administration of a treatment allows quantification of individual responses and determination of the consistency of responses. We determined the consistency of metabolic and exercise responses following repeated administration of sodium bicarbonate (SB). Design and Methods 15 physically active males (age 25 +/- 4 y; body mass 76.0 +/- 7.3 kg; height 1.77 +/- 0.05 m) completed six cycling capacity tests at 110% of maximum power output (CCT110%) following ingestion of either 0.3 of SB (4 trials) or placebo (PL, 2 trials). Blood pH, bicarbonate, base excess and lactate were determined at baseline, pre-exercise, post-exercise and 5-min post-exercise. Total work done (TWD) was recorded as the exercise outcome. Results SB supplementation increased blood pH, bicarbonate and base excess prior to every trial (all p <= 0.001); absolute changes in pH, bicarbonate and base excess from baseline to preexercise were similar in all SB trials (all p > 0.05). Blood lactate was elevated following exercise in all trials (p <= 0.001), and was higher in some, but not all, SB trials compared to PL. TWD was not significantly improved with SB vs. PL in any trial (SB1: +3.6%; SB2 + 0.3%; SB3: +2.1%; SB4: +6.7%; all p > 0.05), although magnitude-based inferences suggested a 93% likely improvement in SB4. Individual analysis showed ten participants improved in at least one SB trial above the normal variation of the test although five improved in none. Conclusions The mechanism for improved exercise with SB was consistently in place prior to exercise, although this only resulted in a likely improvement in one trial. SB does not consistently improve high intensity cycling capacity, with results suggesting that caution should be taken when interpreting the results from single trials as to the efficacy of SB supplementation. (AU)

FAPESP's process: 11/19513-2 - Effects of Chronic Beta-Alanine Supplementation with and without Acute Sodium Bicarbonate Ingestion on Peak Muscle Carnosine Concentration, Washout and High-Intensity Exercise Performance
Grantee:Bryan Saunders
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/04806-0 - Effects of 12 weeks of high-intensity intermittent training on intramuscular carnosine concentrations
Grantee:Vitor de Salles Painelli
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 13/14746-4 - Carnosine metabolism in skeletal muscle: a multi-approach study
Grantee:Bruno Gualano
Support type: Research Projects - Thematic Grants
FAPESP's process: 14/11948-8 - Life without carnosine: development and characterization of a KO rat model for studying the physiological role of carnosine and its implications to physical exercise and muscle metabolism
Grantee:Guilherme Giannini Artioli
Support type: Research Grants - Young Investigators Grants