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Grant number: 12/13026-5
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): November 01, 2012
Effective date (End): January 31, 2016
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:Antonio Herbert Lancha Junior
Grantee:Rafael Pires da Silva
Host Institution: Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Nutritional interventions aiming to regulate intra- and extracellular pH during exercise are claimed to have potential ergogenic effects. Studies have shown that supplementation with beta-alanine (which increases muscle carnosine content) and sodium bicarbonate improve performance in high-intensity intermittent exercises. Because carnosine acts as intracellular buffer and sodium bicarbonate increases the concentration of the extracellular buffer bicarbonate, it is reasonable to assume that these supplements may possibly confer a synergistic improvement in performance if administrated in combination. It has been suggested that the ingestion of beta-alanine and sodium bicarbonate increase the glycolytic system utilization during exercise. However, very few studies have investigated the underlying mechanisms or have taken into account the effects on the energy metabolism. Energetic system contribution can be estimate through the measurement of oxygen consumption and lactate concentration. This method is of importance because is not invasive as a biopsy, for example, what increases the number of individuals as volunteers, the statistic power of data, and the consistence of conclusions. Thus, the aim of this study is to investigate the effects of the combined ingestion of beta-alanine and sodium bicarbonate on intermittent anaerobic exercise performance as well as the response on energetic system contribution during exercise. 40 male athletes, age 18-30 years old will be randomly allocated in 4 groups each containing 10 individuals as follow: 1) beta-alanine + placebo; 2) sodium bicarbonate + placebo; 3) beta-alanine + sodium bicarbonate; 4) placebo + placebo. Supplementation period for beta-alanine will be 4 weeks and 1 week for sodium bicarbonate. Before and after supplementation, individuals will be tested for lower body anaerobic performance (4 30-s all out cycling exercise), oxygen consumption, blood parameters (lactate concentration, pH, bicarbonate, PO2 and PCO2). Participant's anthropometry, body composition and diet will also be record. Data will be analyzed by mixed models analysis of variance for repeated measures. Statistical significance is set at 5%.

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GONCALVES, LIVIA DE SOUZA; PAINELLI, VITOR DE SALLES; YAMAGUCHI, GUILHERME; DE OLIVEIRA, LUANA FARIAS; SAUNDERS, BRYAN; DA SILVA, RAFAEL PIRES; MACIEL, ERIKA; ARTIOLI, GUILHERME GIANNINI; ROSCHEL, HAMILTON; GUALANO, BRUNO. Dispelling the myth that habitual caffeine consumption influences the performance response to acute caffeine supplementation. Journal of Applied Physiology, v. 123, n. 1, p. 213-220, . (11/19513-2, 13/14746-4, 12/13026-5, 13/04806-0)
W. DAS NEVES; L.F. DE OLIVEIRA; R.P. DA SILVA; C.R.R. ALVES; A.H. LANCHA JR.. Fasting: a major limitation for resistance exercise training effects in rodents. Brazilian Journal of Medical and Biological Research, v. 51, n. 1, . (13/04744-4, 12/13026-5)
DA SILVA, RAFAEL PIRES; DE OLIVEIRA, LUANA FARIAS; SAUNDERS, BRYAN; KRATZ, CAROLINE DE ANDRADE; PAINELLI, VITOR DE SALLES; SILVA, VINICIUS DA EIRA; BOUZAS MARINS, JOAO CARLOS; FRANCHINI, EMERSON; GUALANO, BRUNO; ARTIOLI, GUILHERME GIANNINI. Effects of -alanine and sodium bicarbonate supplementation on the estimated energy system contribution during high-intensity intermittent exercise. Amino Acids, v. 51, n. 1, p. 83-96, . (13/14746-4, 16/50438-0, 12/13026-5, 14/11948-8, 13/04806-0)
SAUNDERS, BRYAN; PAINELLI, VITOR DE SALLES; DE OLIVEIRA, LUANA FARIAS; SILVA, VINICIUS DA EIRA; DA SILVA, RAFAEL PIRES; RIANI, LUIZ; FRANCHI, MARIANA; GONCALVES, LIVIA DE SOUZA; HARRIS, ROGER CHARLES; ROSCHEL, HAMILTON; et al. Twenty-four Weeks of beta-Alanine Supplementation on Carnosine Content, Related Genes, and Exercise. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 49, n. 5, p. 896-906, . (13/14746-4, 14/11948-8, 12/13026-5, 11/19513-2, 13/04806-0, 15/22686-7)
SAUNDERS, BRYAN; FRANCHI, MARIANA; DE OLIVEIRA, LUANA FARIAS; SILVA, VINICIUS DA EIRA; DA SILVA, RAFAEL PIRES; PAINELLI, VITOR DE SALLES; RIANI COSTA, LUIZ AUGUSTO; SALE, CRAIG; HARRIS, ROGER CHARLES; ROSCHEL, HAMILTON; et al. 24-Week beta-alanine ingestion does not affect muscle taurine or clinical blood parameters in healthy males. EUROPEAN JOURNAL OF NUTRITION, v. 59, n. 1, p. 57-65, . (13/14746-4, 17/04973-4, 16/50438-0, 12/13026-5, 14/11948-8, 13/04806-0, 15/22686-7)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SILVA, Rafael Pires da. Supplementation of beta-alanine and sodium bicarbonate: effects on energetic systems contribution during high-intensity intermittent exercise. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Escola de Educação Física e Esportes (EEFE/BT) São Paulo.

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