|Support type:||Scholarships in Brazil - Doctorate|
|Effective date (Start):||November 01, 2012|
|Effective date (End):||January 31, 2016|
|Field of knowledge:||Health Sciences - Physical Education|
|Principal Investigator:||Antonio Herbert Lancha Junior|
|Grantee:||Rafael Pires da Silva|
|Home Institution:||Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil|
Nutritional interventions aiming to regulate intra- and extracellular pH during exercise are claimed to have potential ergogenic effects. Studies have shown that supplementation with beta-alanine (which increases muscle carnosine content) and sodium bicarbonate improve performance in high-intensity intermittent exercises. Because carnosine acts as intracellular buffer and sodium bicarbonate increases the concentration of the extracellular buffer bicarbonate, it is reasonable to assume that these supplements may possibly confer a synergistic improvement in performance if administrated in combination. It has been suggested that the ingestion of beta-alanine and sodium bicarbonate increase the glycolytic system utilization during exercise. However, very few studies have investigated the underlying mechanisms or have taken into account the effects on the energy metabolism. Energetic system contribution can be estimate through the measurement of oxygen consumption and lactate concentration. This method is of importance because is not invasive as a biopsy, for example, what increases the number of individuals as volunteers, the statistic power of data, and the consistence of conclusions. Thus, the aim of this study is to investigate the effects of the combined ingestion of beta-alanine and sodium bicarbonate on intermittent anaerobic exercise performance as well as the response on energetic system contribution during exercise. 40 male athletes, age 18-30 years old will be randomly allocated in 4 groups each containing 10 individuals as follow: 1) beta-alanine + placebo; 2) sodium bicarbonate + placebo; 3) beta-alanine + sodium bicarbonate; 4) placebo + placebo. Supplementation period for beta-alanine will be 4 weeks and 1 week for sodium bicarbonate. Before and after supplementation, individuals will be tested for lower body anaerobic performance (4 30-s all out cycling exercise), oxygen consumption, blood parameters (lactate concentration, pH, bicarbonate, PO2 and PCO2). Participant's anthropometry, body composition and diet will also be record. Data will be analyzed by mixed models analysis of variance for repeated measures. Statistical significance is set at 5%.