Elemental fingerprinting of schizophrenia patient blood plasma before and after treatment with antipsychotics

Autor(es)

Sussulini, Alessandra ^{[1, 2, 3]} ; Erbolato, Helena Munhoz ^{[4, 2]} ; Pessoa, Gustavo de Souza ^{[1, 5]} ; Zezzi Arruda, Marco Aurelio ^{[1, 3]} ; Steiner, Johann ^[6] ; Martins-de-Souza, Daniel ^{[7, 8, 4]}

Afiliação do(s) autor(es)

^[1] Univ Campinas UNICAMP, Inst Chem, Dept Analyt Chem, Spectrometry Sample Preparat & Mechanizat Grp GEP, POB 6154, BR-13083970 Spectrometry, SP - Brazil

^[2] Univ Campinas UNICAMP, Inst Chem, Dept Analyt Chem, Lab Bioanalyt & Integrated Omics LaBIOmics, POB 6154, BR-13083970 Campinas, SP - Brazil

^[3] Univ Campinas UNICAMP, Natl Inst Sci & Technol Bioanalyt INCTBio, Inst Chem, POB 6154, BR-13083970 P, SP - Brazil

^[4] Univ Campinas UNICAMP, Inst Biol, Dept Biochem, Lab Neuroprote, BR-13083862 Campinas, SP - Brazil

^[5] CRod Jornalista Francisco Aguirre Proenca, Km 08, BR-13186901 Hortolandia, SP - Brazil

^[6] Univ Magdeburg, Dept Psychiat, Magdeburg - Germany

^[7] UNICAMPs Neurobiol Ctr, Campinas, SP - Brazil

^[8] Conselho Nacl Desenvolvimento Cient & Tecnol, Inst Nacl Biomarcadores Neuropsiquiatria INBION, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE; v. 268, n. 6, p. 565-570, SEP 2018.
• Citações Web of Science: 1

Resumo

Antipsychotics are the main line of treatment for schizophrenia, a disorder that affects about 1% of the worldwide population. Considering the poor performance of antipsychotics on patients, this work aimed at detecting alterations in the elemental profile resulting from the use of this type of medication using an elemental fingerprinting strategy. We evaluated 56 plasma samples from schizophrenia patients by inductively coupled plasma mass spectrometry (ICP-MS) before (t0) and after 6 weeks (t6) of treatment. The level of response of the patients (good vs. poor responders) and the medications taken were considered. Zinc, aluminum, phosphorus, and iron levels were found to be increased, whereas sodium, potassium, calcium, and magnesium levels decreased after treatment. Aluminum presented a higher level in poor responders at t0 when compared to good responders. At t6, iron showed an increased level when compared to t0 for good responders; however, its level remained constant in poor responders. The results of this exploratory study provide clues for further investigations on the role of metal ions in the treatment of schizophrenia. (AU)

• Processo FAPESP: 16/07384-7 - Bioimageamento elementar por meio da ablação a laser e espectrometria de massas com plasma indutivamente acoplado
• Beneficiário: Marco Aurelio Zezzi Arruda
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/13229-1 - Investigação de potenciais biomarcadores do transtorno bipolar usando a estratégia lipidômica
• Beneficiário: Alessandra Sussulini
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/08711-3 - Desenvolvimento de um teste preditivo para medicação bem sucedida e compreensão das bases moleculares da esquizofrenia através da proteômica
• Beneficiário: Daniel Martins-de-Souza
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 14/10068-4 - EMU concedido no processo 13/08711-3: espectrômetro de massas Waters SYNAPT G2-Si HDMs + nanoACQUITY UPLC
• Beneficiário: Daniel Martins-de-Souza
• Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários
• Processo FAPESP: 14/50867-3 - INCT 2014: Instituto Nacional de Ciência e Tecnologia de Bioanalítica
• Beneficiário: Marco Aurelio Zezzi Arruda
• Modalidade de apoio: Auxílio à Pesquisa - Temático