| Full text | |
| Author(s): |
Sussulini, Alessandra
[1, 2, 3]
;
Erbolato, Helena Munhoz
[4, 2]
;
Pessoa, Gustavo de Souza
[1, 5]
;
Zezzi Arruda, Marco Aurelio
[1, 3]
;
Steiner, Johann
[6]
;
Martins-de-Souza, Daniel
[7, 8, 4]
Total Authors: 6
|
| Affiliation: | [1] Univ Campinas UNICAMP, Inst Chem, Dept Analyt Chem, Spectrometry Sample Preparat & Mechanizat Grp GEP, POB 6154, BR-13083970 Spectrometry, SP - Brazil
[2] Univ Campinas UNICAMP, Inst Chem, Dept Analyt Chem, Lab Bioanalyt & Integrated Omics LaBIOmics, POB 6154, BR-13083970 Campinas, SP - Brazil
[3] Univ Campinas UNICAMP, Natl Inst Sci & Technol Bioanalyt INCTBio, Inst Chem, POB 6154, BR-13083970 P, SP - Brazil
[4] Univ Campinas UNICAMP, Inst Biol, Dept Biochem, Lab Neuroprote, BR-13083862 Campinas, SP - Brazil
[5] CRod Jornalista Francisco Aguirre Proenca, Km 08, BR-13186901 Hortolandia, SP - Brazil
[6] Univ Magdeburg, Dept Psychiat, Magdeburg - Germany
[7] UNICAMPs Neurobiol Ctr, Campinas, SP - Brazil
[8] Conselho Nacl Desenvolvimento Cient & Tecnol, Inst Nacl Biomarcadores Neuropsiquiatria INBION, Sao Paulo - Brazil
Total Affiliations: 8
|
| Document type: | Journal article |
| Source: | EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE; v. 268, n. 6, p. 565-570, SEP 2018. |
| Web of Science Citations: | 1 |
| Abstract | |
Antipsychotics are the main line of treatment for schizophrenia, a disorder that affects about 1% of the worldwide population. Considering the poor performance of antipsychotics on patients, this work aimed at detecting alterations in the elemental profile resulting from the use of this type of medication using an elemental fingerprinting strategy. We evaluated 56 plasma samples from schizophrenia patients by inductively coupled plasma mass spectrometry (ICP-MS) before (t0) and after 6 weeks (t6) of treatment. The level of response of the patients (good vs. poor responders) and the medications taken were considered. Zinc, aluminum, phosphorus, and iron levels were found to be increased, whereas sodium, potassium, calcium, and magnesium levels decreased after treatment. Aluminum presented a higher level in poor responders at t0 when compared to good responders. At t6, iron showed an increased level when compared to t0 for good responders; however, its level remained constant in poor responders. The results of this exploratory study provide clues for further investigations on the role of metal ions in the treatment of schizophrenia. (AU) | |
| FAPESP's process: | 16/07384-7 - Elementary bioimaging through laser ablation and inductively coupled plasma mass spectrometry |
| Grantee: | Marco Aurelio Zezzi Arruda |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 15/13229-1 - Investigation of bipolar disorder potential biomarkers by lipidomics |
| Grantee: | Alessandra Sussulini |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/08711-3 - Developing a predictive test for a successful medication response and understanding the molecular bases of schizophrenia through proteomics |
| Grantee: | Daniel Martins-de-Souza |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 14/10068-4 - Multi-User Equipment approved in grant 13/08711-3: mass spectrometer waters SYNAPT G2-Si HDMS + nanoACQUITY UPLC |
| Grantee: | Daniel Martins-de-Souza |
| Support Opportunities: | Multi-user Equipment Program |
| FAPESP's process: | 14/50867-3 - INCT 2014: National Institute of Science and Technology in Bioanalysis |
| Grantee: | Marco Aurelio Zezzi Arruda |
| Support Opportunities: | Research Projects - Thematic Grants |