Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Attenuated baroreflex in a Parkinson's disease animal model coincides with impaired activation of non-C1 neurons

Texto completo
Autor(es):
Cabral, Lais M. [1] ; Moreira, Thiago S. [2] ; Takakura, Ana C. [1] ; Falquetto, Barbara [1]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, 1524 Prof Lineu Presses Ave, BR-05508000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508000 Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL; v. 225, MAY 2020.
Citações Web of Science: 1
Resumo

Orthostatic hypotension is one of the most common symptoms observed in Parkinson's disease (PD), a neuro-degenerative disease caused by death of dopaminergic neurons in the substantia nigra pars compacta (SNc), and it is associated with denervation of the heart and impairment of the baroreflex. Here, we aimed to investigate if the impaired baroreflex was associated with lower activation of cardiovascular brainstem areas in a 6-hydroxydopamine (6-OHDA) animal model of PD. The PD model was generated with male Wistar rats by injection of 6-OHDA or vehicle into the striatum. After 20 or 60 days, the femoral vein and artery were cannulated to assess cardiovascular parameters during injection of sodium nitroprusside (SNP) or phenylephrine (Phe). Brainstem slices were submitted to immunohistochemistry and immunofluorescence. After 6-OHDA injection, 75% of the dopaminergic neurons in the SNc were absent, confirming establishment of the PD model. Intravenous (iv) injection of SNP generated reduced hypotension and tachycardia response, and the noncatecholaminergic (non-C1) neurons of the rostral ventrolateral medulla (RVLM) were less activated. Additionally, iv injection of Phe increased blood pressure and bradycardia to the same extent and activated equivalent numbers of neurons in the nucleus of the solitary tract and the caudal ventrolateral medulla as well as cholinergic neurons of the dorsal motor nucleus of the vagus and the nucleus ambiguus between control and PD animals. In summary, these data showed that in the PD model, impairment of cardiovascular autonomic control was observed only during deactivation of the baroreflex, which could be related to reduced activation of non-C1 neurons within the RVLM. (AU)

Processo FAPESP: 16/08987-7 - Alterações neuroanatômicas em áreas do tronco encefálico envolvidas no controle cardiovascular durante a ativação ou desativação do barorreflexo em um modelo animal de Doença de Parkinson
Beneficiário:Laís Maria Cardoso Cabral
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 15/11268-0 - Investigação dos mecanismos responsáveis pela degeneração dos neurônios respiratórios do bulbo no modelo animal de Doença de Parkinson
Beneficiário:Bárbara Falquetto
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 16/23281-3 - Regiões encefálicas responsáveis pela neuroplasticidade observada na resposta respiratória induzida por hipercapnia em modelo animal de doença de parkinson
Beneficiário:Ana Carolina Thomaz Takakura
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 15/23376-1 - Núcleo retrotrapezóide, quimiossensibilidade central e automaticidade respiratória
Beneficiário:Thiago dos Santos Moreira
Linha de fomento: Auxílio à Pesquisa - Temático