| Texto completo | |
| Autor(es): |
de Oliveira, Andressa Peres
[1]
;
Issayama, Luidy Kazuo
[1, 2]
;
Betim Pavan, Isadora Carolina
[1, 2, 3]
;
Silva, Fernando Riback
[1, 2]
;
Melo-Hanchuk, Talita Diniz
[1, 2]
;
Simabuco, Fernando Moreira
[3]
;
Kobarg, Jorg
[2]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Univ Estadual Campinas, Inst Biol, Dept Bioquim & Biol Tecidual, Campinas 13083862, SP - Brazil
[2] Univ Estadual Campinas, Fac Ciencias Farmaceut, Campinas 13083871, SP - Brazil
[3] Univ Estadual Campinas, Fac Ciencias Aplicadas, Lab Multidisciplinar Alimentos & Saude, Sao Paulo 13484350 - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo de Revisão |
| Fonte: | Molecules; v. 25, n. 8 APR 2 2020. |
| Citações Web of Science: | 1 |
| Resumo | |
In previous years, several kinases, such as phosphoinositide 3-kinase (PI3K), mammalian target of rapamycin (mTOR), and extracellular-signal-regulated kinase (ERK), have been linked to important human diseases, although some kinase families remain neglected in terms of research, hiding their relevance to therapeutic approaches. Here, a review regarding the NEK family is presented, shedding light on important information related to NEKs and human diseases. NEKs are a large group of homologous kinases with related functions and structures that participate in several cellular processes such as the cell cycle, cell division, cilia formation, and the DNA damage response. The review of the literature points to the pivotal participation of NEKs in important human diseases, like different types of cancer, diabetes, ciliopathies and central nervous system related and inflammatory-related diseases. The different known regulatory molecular mechanisms specific to each NEK are also presented, relating to their involvement in different diseases. In addition, important information about NEKs remains to be elucidated and is highlighted in this review, showing the need for other studies and research regarding this kinase family. Therefore, the NEK family represents an important group of kinases with potential applications in the therapy of human diseases. (AU) | |
| Processo FAPESP: | 14/15982-6 - Consequências de deficiências de reparo de lesões no genoma |
| Beneficiário: | Carlos Frederico Martins Menck |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 18/14818-9 - Estudo de alvos moleculares importantes para o controle do metabolismo em câncer: a via da mTOR/S6K com papel central |
| Beneficiário: | Fernando Moreira Simabuco |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores - Fase 2 |
| Processo FAPESP: | 17/03489-1 - De estudos funcionais à busca de novos inibidores anticâncer: explorando cinases reguladores do ciclo celular da família de NEK humana |
| Beneficiário: | Jörg Kobarg |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 08/57906-3 - Instituto Nacional de Fotônica Aplicada à Biologia Celular - INFABIC |
| Beneficiário: | Hernandes Faustino de Carvalho |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |