| Full text | |
| Author(s): |
de Oliveira, Andressa Peres
[1]
;
Issayama, Luidy Kazuo
[1, 2]
;
Betim Pavan, Isadora Carolina
[1, 2, 3]
;
Silva, Fernando Riback
[1, 2]
;
Melo-Hanchuk, Talita Diniz
[1, 2]
;
Simabuco, Fernando Moreira
[3]
;
Kobarg, Jorg
[2]
Total Authors: 7
|
| Affiliation: | [1] Univ Estadual Campinas, Inst Biol, Dept Bioquim & Biol Tecidual, Campinas 13083862, SP - Brazil
[2] Univ Estadual Campinas, Fac Ciencias Farmaceut, Campinas 13083871, SP - Brazil
[3] Univ Estadual Campinas, Fac Ciencias Aplicadas, Lab Multidisciplinar Alimentos & Saude, Sao Paulo 13484350 - Brazil
Total Affiliations: 3
|
| Document type: | Review article |
| Source: | Molecules; v. 25, n. 8 APR 2 2020. |
| Web of Science Citations: | 1 |
| Abstract | |
In previous years, several kinases, such as phosphoinositide 3-kinase (PI3K), mammalian target of rapamycin (mTOR), and extracellular-signal-regulated kinase (ERK), have been linked to important human diseases, although some kinase families remain neglected in terms of research, hiding their relevance to therapeutic approaches. Here, a review regarding the NEK family is presented, shedding light on important information related to NEKs and human diseases. NEKs are a large group of homologous kinases with related functions and structures that participate in several cellular processes such as the cell cycle, cell division, cilia formation, and the DNA damage response. The review of the literature points to the pivotal participation of NEKs in important human diseases, like different types of cancer, diabetes, ciliopathies and central nervous system related and inflammatory-related diseases. The different known regulatory molecular mechanisms specific to each NEK are also presented, relating to their involvement in different diseases. In addition, important information about NEKs remains to be elucidated and is highlighted in this review, showing the need for other studies and research regarding this kinase family. Therefore, the NEK family represents an important group of kinases with potential applications in the therapy of human diseases. (AU) | |
| FAPESP's process: | 14/15982-6 - Consequences of repair deficiencies in damaged genome |
| Grantee: | Carlos Frederico Martins Menck |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 18/14818-9 - Study of molecular targets important for the control of cancer metabolism: the mTOR/S6K pathway as a central role |
| Grantee: | Fernando Moreira Simabuco |
| Support Opportunities: | Research Grants - Young Investigators Grants - Phase 2 |
| FAPESP's process: | 17/03489-1 - From functional studies to searching for new inhibitors for cancer: exploring kinases that regulate the cell cycle of the human NEK family |
| Grantee: | Jörg Kobarg |
| Support Opportunities: | Research Projects - Thematic Grants |