Anti-inflammatory effects of monoterpenoids in rats with TNBS-induced colitis

Autor(es)

Alexandrino, Thais Dolfini ^[1] ; Tomazini Munhoz Moya, Amanda Maria ^[1] ; Madureira de Medeiros, Tiago Daniel ^[1] ; Morari, Joseane ^[2] ; Velloso, Licio Augusto ^[2] ; Leal, Raquel Franco ^[2] ; Marostica, Mario Roberto ^[1] ; Pastore, Glaucia Maria ^[1] ; Betim Cazarin, Cinthia Bau ^[1] ; Bicas, Juliano Lemos ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Sch Food Engn, Rua Monteiro Lobato 80, BR-13083862 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Sch Med Sci, Rua Tessalia Vieira Camargo 126, BR-13083887 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PHARMANUTRITION; v. 14, DEC 2020.
• Citações Web of Science: 0

Resumo

Background: Ulcerative colitis is an idiopathic disease, characterized by an inflammation of the intestinal mucosa. Considering that the dietary pattern can be related to both its occurrence and its protection, studies with food terpenoids have been conducted, indicating that such compounds present an anti-inflammatory effect in experimental models. Methods: The present study evaluated the effect of AIN-93 G diets supplemented (1470 mg/kg) with different enantiomers (R-(+)and S-(-)-) of alpha-terpineol and limonene-1,2-diol on TNBS-induced colitis in male Wistar rats. The colon was analyzed in terms of: assessment of tissue damage, levels of cytokines, antioxidant status, besides gene expression of tight junction proteins, proand anti-inflammatory cytokines. Results: Anti-inflammatory effect was observed, since monoterpenoid consumption reduced the TNF-alpha levels up to five times, in most groups. Moreover, supplemented diets, particularly with S-(-)-alpha-terpineol and limonene1,2-diol, promoted a significant increase in gene expression of the anti-inflammatory cytokine IL-10. Conclusions: In general, no significant differences were observed between the effects of alpha-terpineol enantiomers. The results described in this article encourage future studies on the use of monoterpenoids to help treat colitis and inflammatory diseases. (AU)

• Processo FAPESP: 16/21619-7 - Avaliação das propriedades biológicas de produtos da biotransformação do limoneno
• Beneficiário: Juliano Lemos Bicas
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/50333-1 - Cobra: nova plataforma de descoberta de compostos para identificação rápida e de baixo custo de bioativo com efeitos benéficos originários de plantas brasileiras
• Beneficiário: Glaucia Maria Pastore
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 15/13320-9 - Efeito do azeite da polpa e do chá das folhas do abacate da variedade Hass associado à atividade física no tratamento da obesidade induzida por dieta hiperlipídica
• Beneficiário: Mário Roberto Maróstica Junior
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/11069-5 - Ação de berries brasileiras sobre parâmetros metabólicos e desempenho cognitivo de animais obesos
• Beneficiário: Mário Roberto Maróstica Junior
• Modalidade de apoio: Auxílio à Pesquisa - Regular